about
Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leakDefects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillationPhosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmiasEnhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure.Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndromeMolecular evolution of the junctophilin gene familyCalcium dysregulation in atrial fibrillation: the role of CaMKIIGenetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling.FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac deathSudden unexplained death caused by cardiac ryanodine receptor (RyR2) mutationsMutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humansIncreased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFαAnalysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in miceCircadian rhythms govern cardiac repolarization and arrhythmogenesisStabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmiasCalmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1.Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death.Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation.Novel insights in the congenital long QT syndrome.Cardiac rupture complicating myocardial infarction.The molecular basis of catecholaminergic polymorphic ventricular tachycardia: what are the different hypotheses regarding mechanisms?Loss-of-Function SCN5A Mutations Associated With Sinus Node Dysfunction, Atrial Arrhythmias, and Poor Pacemaker CaptureRole of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease.Digoxin treatment in heart failure--unveiling risk by cluster analysis of DIG data.Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development.Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1.Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillationPitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specificationCaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury.Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.Human stanniocalcin-1 suppresses angiotensin II-induced superoxide generation in cardiomyocytes through UCP3-mediated anti-oxidant pathway.CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome.Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.Long-term simulated microgravity causes cardiac RyR2 phosphorylation and arrhythmias in mice.Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation.Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice.Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance
P50
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P50
description
investigador
@es
researcher
@en
name
Xander H T Wehrens
@en
type
label
Xander H T Wehrens
@en
prefLabel
Xander H T Wehrens
@en
P31
P496
0000-0001-5044-672X