about
Deficiency of the cytoskeletal protein SPECC1L leads to oblique facial cleftingTransfusion independence and HMGA2 activation after gene therapy of human β-thalassaemiaAngiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2Atypical BSE (BASE) transmitted from asymptomatic aging cattle to a primatePioglitazone together with imatinib in chronic myeloid leukemia: A proof of concept study.Phenotypic and functional changes induced in hematopoietic stem/progenitor cells after gamma-ray radiation exposure.Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesisDynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trialImmortalization of a primate bipotent epithelial liver stem cell.Permanent and panerythroid correction of murine beta thalassemia by multiple lentiviral integration in hematopoietic stem cells.Preclinical evaluation of efficacy and safety of an improved lentiviral vector for the treatment of β-thalassemia and sickle cell disease.Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics.Is normal hematopoiesis maintained solely by long-term multipotent stem cells?Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy.Correction of murine β-thalassemia after minimal lentiviral gene transfer and homeostatic in vivo erythroid expansion.A method to sequence and quantify DNA integration for monitoring outcome in gene therapy.Distribution of lentiviral vector integration sites in mice following therapeutic gene transfer to treat β-thalassemia.Stem cell factor-displaying simian immunodeficiency viral vectors together with a low conditioning regimen allow for long-term engraftment of gene-marked autologous hematopoietic stem cells in macaques.Highly efficient in vitro and in vivo delivery of functional RNAs using new versatile MS2-chimeric retrovirus-like particles.Erythropoietin and IGF-1 signaling synchronize cell proliferation and maturation during erythropoiesisGene Therapy of the β-Hemoglobinopathies by Lentiviral Transfer of the β(A(T87Q))-Globin Gene.Induced pluripotent stem cell generation from a man carrying a complex chromosomal rearrangement as a genetic model for infertility studiesAdvances in stem cell transplantation and gene therapy in the β-hemoglobinopathies.BET bromodomain inhibition rescues erythropoietin differentiation of human erythroleukemia cell line UT7.Activation and inhibition of the erythropoietin receptor by a membrane-anchored erythropoietin.Design of a trans protease lentiviral packaging system that produces high titer virus.High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells.Survival of liver failure pigs by transplantation of reversibly immortalized human hepatocytes with Tamoxifen-mediated self-recombination.Postnatal neovascularization by endothelial progenitor cells immortalized with the simian virus 40T antigen gene.Gene Therapy in a Patient with Sickle Cell Disease.A human beta-cell line for transplantation therapy to control type 1 diabetes.Establishment of an immortalized human-liver endothelial cell line with SV40T and hTERT.Glycoprotein 170 induces platelet-activating factor receptor membrane expression and confers tumor cell hypersensitivity to NK-dependent cell lysis.Establishment of a highly differentiated immortalized human cholangiocyte cell line with SV40T and hTERT.Transplantation of reversibly immortalized insulin-secreting human hepatocytes controls diabetes in pancreatectomized pigs.Immortalization of bone marrow-derived human mesenchymal stem cells by removable simian virus 40T antigen gene: analysis of the ability to support expansion of cord blood hematopoietic progenitor cells.A reversibly immortalized human hepatocyte cell line as a source of hepatocyte-based biological support.Treatment of liver failure in rats with end-stage cirrhosis by transplantation of immortalized hepatocytes.Controlled expansion of human endothelial cell populations by Cre-loxP-based reversible immortalization.HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia.
P50
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P50
name
Philippe Leboulch
@en
type
label
Philippe Leboulch
@en
prefLabel
Philippe Leboulch
@en