High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells. - Wikidata - wikimedia - TriplyDB

High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells.

High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells.

http://www.wikidata.org/entity/Q40051271

about

Current and future alternative therapies for beta-thalassemia major Beta-globin LCR and intron elements cooperate and direct spatial reorganization for gene therapy Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration Future alternative therapies for β-thalassemia.Genotoxic potential of lineage-specific lentivirus vectors carrying the beta-globin locus control region.The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice.High-efficiency transduction of primary human hematopoietic stem cells and erythroid lineage-restricted expression by optimized AAV6 serotype vectors in vitro and in a murine xenograft model in vivo Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer.Distribution of lentiviral vector integration sites in mice following therapeutic gene transfer to treat β-thalassemia.Hematopoietic stem cells: transcriptional regulation, ex vivo expansion and clinical application.Efficient marking of human cells with rapid but transient repopulating activity in autografted recipients Thalassemia: the continued challenge.Gene therapy: can neural stem cells deliver?Modification of globin gene expression by RNA targeting strategies.Gene therapy for treatment of inherited haematological disorders.Gene Therapy of the β-Hemoglobinopathies by Lentiviral Transfer of the β(A(T87Q))-Globin Gene.In vivo selection of genetically modified erythroblastic progenitors leads to long-term correction of beta-thalassemia.Unaltered repopulation properties of mouse hematopoietic stem cells transduced with lentiviral vectors.Exploitation of stem cell homing for gene delivery.On the road to gene therapy for beta-thalassemia and sickle cell anemia.Current status of globin gene therapy for the treatment of beta-thalassaemia.Erythroid-specific expression of beta-globin by the sleeping beauty transposon for Sickle cell disease.Therapy for beta-globinopathies: a brief review and determinants for successful and safe correction.Physiological and tissue-specific vectors for treatment of inherited diseases.Gene therapy in thalassemia and hemoglobinopathies.Alternative options for DNA-based experimental therapy of β-thalassemia.Recent advances in gene therapy for thalassemia.Development of gene therapy for thalassemia.Recent trends in the gene therapy of β-thalassemia.VENTX induces expansion of primitive erythroid cells and contributes to the development of acute myeloid leukemia in mice.Functional regulation of pre-B-cell leukemia homeobox interacting protein 1 (PBXIP1/HPIP) in erythroid differentiation.Design of a trans protease lentiviral packaging system that produces high titer virus.Lenti in red: progress in gene therapy for human hemoglobinopathies.Prolonged adherence of human immunodeficiency virus-derived vector particles to hematopoietic target cells leads to secondary transduction in vitro and in vivo.Gene Therapy for Hemoglobinopathies: Tremendous Successes and Remaining Caveats.Characterization of Epithelial Progenitors in Normal Human Palatine Tonsils and Their HPV16 E6/E7-Induced Perturbation.Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells.A New Approach in Gene Therapy of Glioblastoma Multiforme: Human Olfactory Ensheathing Cells as a Novel Carrier for Suicide Gene Delivery.Retroviral vectors encoding ADA regulatory locus control region provide enhanced T-cell-specific transgene expression.Locus control region elements HS1 and HS4 enhance the therapeutic efficacy of globin gene transfer in beta-thalassemic mice.

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P2860

High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells.

http://www.wikidata.org/entity/Q40051271

description

2004 nî lūn-bûn

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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2004年论文

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2004年论文

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name

High-level beta-globin express ...... f human cord blood stem cells.

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High-level beta-globin express ...... f human cord blood stem cells.

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High-level beta-globin express ...... f human cord blood stem cells.

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Journal of Clinical Investigation

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High-level beta-globin express ...... f human cord blood stem cells.

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P2093

Connie J Eaves

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Karen A Westerman

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Mary E Fabry

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Patricia M Rosten

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Patrick Tang

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Robert Pawliuk

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Ronald L Nagel

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Suzan Imren

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P2860

Initial sequencing and analysis of the human genome

The Sequence of the Human Genome

The "beta-like-globin" gene domain in human erythroid cells

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors

Transcription start regions in the human genome are favored targets for MLV integration

HIV-1 integration in the human genome favors active genes and local hotspots

Human hematopoietic stem cells stimulated to proliferate in vitro lose engraftment potential during their S/G(2)/M transit and do not reenter G(0).

The beta-thalassemias.

A novel, rapid method for the isolation of terminal sequences from yeast artificial chromosome (YAC) clones.

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953-962

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7

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114

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R Keith Humphries

Philippe Leboulch

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2004-10-01T00:00:00Z

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15467834

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518665

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