Artemisinin, an Endoperoxide Antimalarial, Disrupts the Hemoglobin Catabolism and Heme Detoxification Systems in Malarial Parasite - sprookjes - yvandenbroek - TriplyDB

Artemisinin, an Endoperoxide Antimalarial, Disrupts the Hemoglobin Catabolism and Heme Detoxification Systems in Malarial Parasite

Artemisinin, an Endoperoxide Antimalarial, Disrupts the Hemoglobin Catabolism and Heme Detoxification Systems in Malarial Parasite

http://www.wikidata.org/entity/Q22061847

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Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation Artemisinin and a Series of Novel Endoperoxide Antimalarials Exert Early Effects on Digestive Vacuole Morphology Transition-state inhibitors of purine salvage and other prospective enzyme targets in malaria Artemisinin Action and Resistance in Plasmodium falciparum Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation target Evidence for the contribution of the hemozoin synthesis pathway of the murine Plasmodium yoelii to the resistance to artemisinin-related drugs Anti-plasmodial polyvalent interactions in Artemisia annua L. aqueous extract--possible synergistic and resistance mechanisms Ligand binding reveals a role for heme in translationally-controlled tumor protein dimerization.Cryo transmission X-ray imaging of the malaria parasite, P. falciparum.Reaction of artemisinin with haemoglobin: implications for antimalarial activity.The binding modes and binding affinities of artemisinin derivatives with Plasmodium falciparum Ca2+-ATPase (PfATP6).Identification of essential histidine residues involved in heme binding and Hemozoin formation in heme detoxification protein from Plasmodium falciparum.Ligands of the peripheral benzodiazepine receptor are potent inhibitors of Plasmodium falciparum and Toxoplasma gondii in vitro Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin.Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production Plasmodium drug targets outside the genetic control of the parasite.Discovery, mechanisms of action and combination therapy of artemisinin Emerging targets for antimalarial drugs.Mechanisms of in situ activation for peroxidic antimalarials.Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities.Sequence characterized amplified region marker as a tool for selection of high-artemisinin containing species of Artemisia.Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7.Prospects for the treatment of drug-resistant malaria parasites.Mechanism of artemisinin resistance for malaria PfATP6 L263 mutations and discovering potential antimalarials: An integrated computational approach.Recent highlights in antimalarial drug resistance and chemotherapy research.Organism-like formation of Schistosoma hemozoin and its function suggest a mechanism for anti-malarial action of artemisinin.Artemisinin derivative artesunate induces radiosensitivity in cervical cancer cells in vitro and in vivo.Next-Generation Antimalarial Drugs: Hybrid Molecules as a New Strategy in Drug Design.Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential Honoring antiparasitics: The 2015 Nobel Prize in Physiology or Medicine.Artesunate induces necrotic cell death in schwannoma cells.Artemisinin and its derivatives in treating protozoan infections beyond malaria.Oxidative stress in malaria and artemisinin combination therapy: Pros and Cons.Immunoprecipitation of [(3)H]dihydroartemisinin translationally controlled tumor protein (TCTP) adducts from Plasmodium falciparum-infected erythrocytes by using anti-TCTP antibodies Microarray expression profiles of angiogenesis-related genes predict tumor cell response to artemisinins.Antimalarial quinolines and artemisinin inhibit endocytosis in Plasmodium falciparum The Effects of Artemisinin on the Cytolytic Activity of Natural Killer (NK) Cells Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance.Mechanism of malarial haem detoxification inhibition by chloroquine Safety of Artemisinin-Based Combination Therapies in Nigeria: A Cohort Event Monitoring Study.

P2860

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P2860

Artemisinin, an Endoperoxide Antimalarial, Disrupts the Hemoglobin Catabolism and Heme Detoxification Systems in Malarial Parasite

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R. L. Singh

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P2860

On the molecular mechanism of chloroquine's antimalarial action

Hemoglobin metabolism in the malaria parasite Plasmodium falciparum

The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin

Hemoglobin degradation in the malaria parasite Plasmodium falciparum: an ordered process in a unique organelle

Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease

Plasmodium vinckei petteri: identification of the stages sensitive to arteether.

Malaria: new developments in treatment and prevention.

An overview of chemotherapeutic targets for antimalarial drug discovery.

Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway

Qinghaosu (artemisinin): an antimalarial drug from China.

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