Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit
about
Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteinsA vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesisCrystal structure of the GTPase-activating protein-related domain from IQGAP1SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55Structure of the BH domain from graf and its implications for Rho GTPase recognitionThe BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAPCharacterization of the interactions between the small GTPase Cdc42 and its GTPase-activating proteins and putative effectors. Comparison of kinetic properties of Cdc42 binding to the Cdc42-interactive domainsStructural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoAThe rat myosin myr 5 is a GTPase-activating protein for Rho in vivo: essential role of arginine 1695Assembly and Molecular Architecture of the Phosphoinositide 3-Kinase p85α Homodimer.Regulation of the PI3K pathway through a p85α monomer-homodimer equilibriumIntermolecular interactions of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase.Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).Combinatorial Domain Hunting: An effective approach for the identification of soluble protein domains adaptable to high-throughput applications.Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug designA high-throughput immobilized bead screen for stable proteins and multi-protein complexes.Experimental mapping of soluble protein domains using a hierarchical approachIdentification of mutations in distinct regions of p85 alpha in urothelial cancer.Identification of the GTPase-activating protein DEP domain containing 1B (DEPDC1B) as a transcriptional target of Pitx2JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.Rho/RacGAPs: embarras de richesse?Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutantsThe phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications.The regulation of class IA PI 3-kinases by inter-subunit interactions.Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking.Physiological mechanisms of signal termination in biological systems.Inhibition and termination of physiological responses by GTPase activating proteins.Chemoattractant-stimulated NF-kappaB activation is dependent on the low molecular weight GTPase RhoA.The Rho-GAP Bem2p plays a GAP-independent role in the morphogenesis checkpointBinding of a diphosphotyrosine-containing peptide that mimics activated platelet-derived growth factor receptor beta induces oligomerization of phosphatidylinositol 3-kinase.Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα.The interaction of Ras with GTPase-activating proteins.Using structure to define the function of phosphoinositide 3-kinase family members.Requirement of phosphatidylinositol 3-kinase activity for bradykinin stimulation of NF-kappaB activation in cultured human epithelial cells.Structure of the Toll/Interleukin-1 Receptor (TIR) Domain of the B-cell Adaptor That Links Phosphoinositide Metabolism with the Negative Regulation of the Toll-like Receptor (TLR) Signalosome.Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes.New Insights into PI3K Inhibitor Design using X-ray Structures of PI3Kα Complexed with a Potent Lead Compound.
P2860
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P2860
Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit
description
1996 nî lūn-bûn
@nan
1996 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
name
Crystal structure of the break ...... ide 3-kinase p85 alpha subunit
@ast
Crystal structure of the break ...... ide 3-kinase p85 alpha subunit
@en
Crystal structure of the break ...... ide 3-kinase p85 alpha subunit
@nl
type
label
Crystal structure of the break ...... ide 3-kinase p85 alpha subunit
@ast
Crystal structure of the break ...... ide 3-kinase p85 alpha subunit
@en
Crystal structure of the break ...... ide 3-kinase p85 alpha subunit
@nl
prefLabel
Crystal structure of the break ...... ide 3-kinase p85 alpha subunit
@ast
Crystal structure of the break ...... ide 3-kinase p85 alpha subunit
@en
Crystal structure of the break ...... ide 3-kinase p85 alpha subunit
@nl
P2860
P356
P1476
Crystal structure of the break ...... ide 3-kinase p85 alpha subunit
@en
P2093
L C Cantley
S C Harrison
P2860
P304
P356
10.1073/PNAS.93.25.14373
P407
P577
1996-12-10T00:00:00Z