Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues
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LNCaP Atlas: gene expression associated with in vivo progression to castration-recurrent prostate cancerMice with a targeted disruption of the Fgfrl1 gene die at birth due to alterations in the diaphragmMultiple congenital malformations of Wolf-Hirschhorn syndrome are recapitulated in Fgfrl1 null miceA place for precision medicine in bladder cancer: targeting the FGFRs.FGFRL1 is a neglected putative actor of the FGF signalling pathway present in all major metazoan phylaComparison of the receptor FGFRL1 from sea urchins and humans illustrates evolution of a zinc binding motif in the intracellular domain.The FGFRL1 receptor is shed from cell membranes, binds fibroblast growth factors (FGFs), and antagonizes FGF signaling in Xenopus embryosExamination of FGFRL1 as a candidate gene for diaphragmatic defects at chromosome 4p16.3 shows that Fgfrl1 null mice have reduced expression of Tpm3, sarcomere genes and Lrtm1 in the diaphragm.Targeted disruption of the intracellular domain of receptor FgfrL1 in mice.Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signalingWolf-Hirschhorn syndrome facial dysmorphic features in a patient with a terminal 4p16.3 deletion telomeric to the WHSCR and WHSCR 2 regions.Rapid fusion and syncytium formation of heterologous cells upon expression of the FGFRL1 receptor.The Fibroblast Growth Factor signaling pathwayIdentification of a novel FGFRL1 MicroRNA target site polymorphism for bone mineral density in meta-analyses of genome-wide association studies.Genome-wide comparison of FGFRL1 with structurally related surface receptors.Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiencyFibroblast growth factor receptor like-1 (FGFRL1) interacts with SHP-1 phosphatase at insulin secretory granules and induces beta-cell ERK1/2 protein activation.Receptor FGFRL1 does not promote cell proliferation but induces cell adhesionEvidence that the novel receptor FGFRL1 signals indirectly via FGFR1.Receptor FGFRL1 acts as a tumor suppressor in nude mice when overexpressed in HEK 293 Tet-On cells.Multistage genome-wide association meta-analyses identified two new loci for bone mineral densityBiology of FGFRL1, the fifth fibroblast growth factor receptor.Role of FGFRL1 and other FGF signaling proteins in early kidney development.An integrated genomic, transcriptional and protein investigation of FGFRL1 as a putative 4p16.3 deletion target in bladder cancer.FGFRL1 Promotes Ovarian Cancer Progression by Crosstalk with Hedgehog Signaling.
P2860
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P248
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P2860
Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Characterization of FGFRL1, a ...... expressed in skeletal tissues
@ast
Characterization of FGFRL1, a ...... expressed in skeletal tissues
@en
Characterization of FGFRL1, a ...... expressed in skeletal tissues
@en-gb
Characterization of FGFRL1, a ...... expressed in skeletal tissues
@nl
type
label
Characterization of FGFRL1, a ...... expressed in skeletal tissues
@ast
Characterization of FGFRL1, a ...... expressed in skeletal tissues
@en
Characterization of FGFRL1, a ...... expressed in skeletal tissues
@en-gb
Characterization of FGFRL1, a ...... expressed in skeletal tissues
@nl
prefLabel
Characterization of FGFRL1, a ...... expressed in skeletal tissues
@ast
Characterization of FGFRL1, a ...... expressed in skeletal tissues
@en
Characterization of FGFRL1, a ...... expressed in skeletal tissues
@en-gb
Characterization of FGFRL1, a ...... expressed in skeletal tissues
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P2093
P2860
P921
P3181
P356
P1476
Characterization of FGFRL1, a ...... expressed in skeletal tissues
@en
P2093
Lei Zhuang
Markus Wiedemann
Sara Taeschler
P2860
P304
33857-33865
P3181
P356
10.1074/JBC.M300281200
P407
P50
P577
2003-06-17T00:00:00Z