Hdmx modulates the outcome of p53 activation in human tumor cells - sprookjes - yvandenbroek - TriplyDB

Hdmx modulates the outcome of p53 activation in human tumor cells

Hdmx modulates the outcome of p53 activation in human tumor cells

http://www.wikidata.org/entity/Q28257444

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MdmX is a substrate for the deubiquitinating enzyme USP2a Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53 Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy Clinical Overview of MDM2/X-Targeted Therapies Small molecule compounds targeting the p53 pathway: are we finally making progress?Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization Human serum albumin and p53-activating peptide fusion protein is able to promote apoptosis and deliver fatty acid-modified molecules Impact of MDM2 309T>G polymorphism on sarcomagenesis Regulating the p53 pathway: in vitro hypotheses, in vivo veritas MDM4 (MDMX) and its Transcript Variants.Implementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits.N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53.High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia.Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.Characterization and optimization of a novel protein-protein interaction biosensor high-content screening assay to identify disruptors of the interactions between p53 and hDM2.Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation.A human herpesvirus microRNA inhibits p21 expression and attenuates p21-mediated cell cycle arrest MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines.MDM2 oligomers: antagonizers of the guardian of the genome.Beta-peptides with improved affinity for hDM2 and hDMX.Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation MDM2, MDMX and p53 in oncogenesis and cancer therapy A fluorescent-based high-throughput screening assay for small molecules that inhibit the interaction of MdmX with p53.p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors.Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP.MDM2 promotes invasion and metastasis in invasive ductal breast carcinoma by inducing matrix metalloproteinase-9.Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells.Stochastic modeling and simulation of the p53-MDM2/MDMX loop Wild type p53 reactivation: from lab bench to clinic.Functional p53 signaling in Kaposi's sarcoma-associated herpesvirus lymphomas: implications for therapy.Designer macrocyclic organo-peptide hybrids inhibit the interaction between p53 and HDM2/X by accommodating a functional α-helix.Abnormal MDMX degradation in tumor cells due to ARF deficiency Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation Genome and network visualization facilitates the analyses of the effects of drugs and mutations on protein-protein and drug-protein networks.MDM2 and MDM4: p53 regulators as targets in anticancer therapy.Drug resistance to inhibitors of the human double minute-2 E3 ligase is mediated by point mutations of p53, but can be overcome with the p53 targeting agent RITA.Ubiquitylation of p53 by the APC/C inhibitor Trim39.

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P2860

Hdmx modulates the outcome of p53 activation in human tumor cells

http://www.wikidata.org/entity/Q28257444

description

2006 nî lūn-bûn

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2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

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2006年論文

@zh-tw

2006年论文

@wuu

name

Hdmx modulates the outcome of p53 activation in human tumor cells

@ast

Hdmx modulates the outcome of p53 activation in human tumor cells

@en

Hdmx modulates the outcome of p53 activation in human tumor cells

@nl

type

label

Hdmx modulates the outcome of p53 activation in human tumor cells

@ast

Hdmx modulates the outcome of p53 activation in human tumor cells

@en

Hdmx modulates the outcome of p53 activation in human tumor cells

@nl

prefLabel

Hdmx modulates the outcome of p53 activation in human tumor cells

@ast

Hdmx modulates the outcome of p53 activation in human tumor cells

@en

Hdmx modulates the outcome of p53 activation in human tumor cells

@nl

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P1433

Journal of Biological Chemistry

P1476

Hdmx modulates the outcome of p53 activation in human tumor cells

@en

P2093

Ee Tsin Wong

http://www.w3.org/2001/XMLSchema#string

Geoffrey M Wahl

http://www.w3.org/2001/XMLSchema#string

Jayne M Stommel

http://www.w3.org/2001/XMLSchema#string

Mark Wade

http://www.w3.org/2001/XMLSchema#string

Mengjia Tang

http://www.w3.org/2001/XMLSchema#string

P2860

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.

Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.

14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation

Isolation and identification of the human homolog of a new p53-binding protein, Mdmx

Mdm2 promotes the rapid degradation of p53

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.

Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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33036-44

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scholarly article

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2265034

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10.1074/JBC.M605405200

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P433

44

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P478

281

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P577

2006-11-03T00:00:00Z

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P698

16905769

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