Growth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signaling
about
A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cellsRegulatory and signaling properties of the Vav familyInteraction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cellsCell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand RecognitionNovel recognition mode between Vav and Grb2 SH3 domainsReceptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinaseUnifying concepts in CD28, ICOS and CTLA4 co-receptor signallingThe C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motifCD28 and CTLA-4 coreceptor expression and signal transductionGrb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interactionQuantitative analysis by surface plasmon resonance of CD28 interaction with cytoplasmic adaptor molecules Grb2, Gads and p85 PI3K.Signals and sequences that control CD28 localization to the central region of the immunological synapse.Specificity and affinity motifs for Grb2 SH2-ligand interactionsAn enigmatic tail of CD28 signaling.Vav proteins, adaptors and cell signaling.NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells.T-cell regulation by CD28 and CTLA-4.CD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76?Changes in actin dynamics at the T-cell/APC interface: implications for T-cell anergy?Impairment of immunological synapse formation in adaptively tolerant T cellsMolecular modifiers of T cell antigen receptor triggering threshold: the mechanism of CD28 costimulatory receptor.Independent CD28 signaling via VAV and SLP-76: a model for in trans costimulation.Vav1 Regulates T-Cell Activation through a Feedback Mechanism and Crosstalk between the T-Cell Receptor and CD28.Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation.A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant.Targeted knock-in mice expressing mutations of CD28 reveal an essential pathway for costimulationThe vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface.PD-1 signaling in primary T cellsCD28 co-signaling in the adaptive immune response.Biased binding of class IA phosphatidyl inositol 3-kinase subunits to inducible costimulator (CD278).CD28 Costimulation: From Mechanism to Therapy.Cutting edge: A double-mutant knockin of the CD28 YMNM and PYAP motifs reveals a critical role for the YMNM motif in regulation of T cell proliferation and Bcl-xL expression.Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex.Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse.TcR and TcR-CD28 engagement of protein kinase B (PKB/AKT) and glycogen synthase kinase-3 (GSK-3) operates independently of guanine nucleotide exchange factor VAV-1.CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription.TCR and CD28 activate the transcription factor NF-κB in T-cells via distinct adaptor signaling complexes.CD28-dependent HIV-1 transcription is associated with Vav, Rac, and NF-kappa B activation.Novel role of phosphatidylinositol 3-kinase in CD28-mediated costimulation.
P2860
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P2860
Growth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signaling
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Growth factor receptor-bound p ...... 8 and its role in co-signaling
@ast
Growth factor receptor-bound p ...... 8 and its role in co-signaling
@en
Growth factor receptor-bound p ...... 8 and its role in co-signaling
@en-gb
Growth factor receptor-bound p ...... 8 and its role in co-signaling
@nl
type
label
Growth factor receptor-bound p ...... 8 and its role in co-signaling
@ast
Growth factor receptor-bound p ...... 8 and its role in co-signaling
@en
Growth factor receptor-bound p ...... 8 and its role in co-signaling
@en-gb
Growth factor receptor-bound p ...... 8 and its role in co-signaling
@nl
prefLabel
Growth factor receptor-bound p ...... 8 and its role in co-signaling
@ast
Growth factor receptor-bound p ...... 8 and its role in co-signaling
@en
Growth factor receptor-bound p ...... 8 and its role in co-signaling
@en-gb
Growth factor receptor-bound p ...... 8 and its role in co-signaling
@nl
P2093
P2860
P356
P1476
Growth factor receptor-bound p ...... 8 and its role in co-signaling
@en
P2093
P2860
P304
P356
10.1074/JBC.273.1.296
P407
P577
1998-01-02T00:00:00Z