ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
about
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptorsInteraction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondinMouse Models Recapitulating Human Adrenocortical Tumors: What Is Lacking?Control of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in CancerFrizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat CancerWnt signaling in cancer stem cells and colon cancer metastasisPancreatic Cancer GeneticsBridging academic science and clinical research in the search for novel targeted anti-cancer agentsIn a Class of Their Own - RXFP1 and RXFP2 are Unique Members of the LGR FamilyLGR4 and Its Role in Intestinal Protection and Energy MetabolismChemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative MedicineEpidemiology and Inherited Predisposition for Sporadic Pancreatic AdenocarcinomaKeeping Wnt signalosome in check by vesicular trafficG Protein-Coupled Receptor Signaling in Stem Cells and CancerThe structural basis of R-spondin recognition by LGR5 and RNF43Structural basis for R-spondin recognition by LGR4/5/6 receptorsStructural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondinStructures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for SignalingLRP5 and LRP6 in development and diseaseFrizzled Receptors in Development and DiseaseRole of E3 ubiquitin ligases in gastric cancerNine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive errorLgr4 gene deficiency increases susceptibility and severity of dextran sodium sulfate-induced inflammatory bowel disease in miceN-Glycosylation of Human R-Spondin 1 Is Required for Efficient Secretion and Stability but Not for Its Heparin Binding AbilityCrystal structure of LGR4-Rspo1 complex: insights into the divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors (LGRs).Intrinsic disorder in spondins and some of their interacting partners.Whole-exome sequencing characterizes the landscape of somatic mutations and copy number alterations in adrenocortical carcinoma.Diversity of Precursor Lesions For Pancreatic Cancer: The Genetics and Biology of Intraductal Papillary Mucinous NeoplasmControl of signaling molecule range during developmental patterningE3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function.Salinomycin suppresses LRP6 expression and inhibits both Wnt/β-catenin and mTORC1 signaling in breast and prostate cancer cellsComputational biophysical, biochemical, and evolutionary signature of human R-spondin family proteins, the member of canonical Wnt/β-catenin signaling pathwayGenome-wide association study identifies multiple susceptibility loci for pancreatic cancer.Updating the Wnt pathways.The genetic make-up of ovarian development and function: the focus on the transcription factor FOXL2.Use of a molecular genetic platform technology to produce human Wnt proteins reveals distinct local and distal signaling abilitiesWnt signaling and the control of human stem cell fate.Complex network-driven view of genomic mechanisms underlying Parkinson's disease: analyses in dorsal motor vagal nucleus, locus coeruleus, and substantia nigraRecurrent chromosome 22 deletions in osteoblastoma affect inhibitors of the Wnt/beta-catenin signaling pathway.
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ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
description
2012 nî lūn-bûn
@nan
2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
@ast
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
@en
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
@en-gb
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
@nl
type
label
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
@ast
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
@en
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
@en-gb
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
@nl
prefLabel
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
@ast
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
@en
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
@en-gb
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
@en
P2093
Craig Mickanin
Emma Oster
Fabrizio C Serluca
Heinz Ruffner
Huai-Xiang Hao
Jeffery A Porter
Marc W Kirschner
P2860
P2888
P304
P3181
P356
10.1038/NATURE11019
P407
P577
2012-04-29T00:00:00Z
P5875
P6179
1024893634