Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression
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RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovaryHuman RSPO1/R-spondin1 is expressed during early ovary development and augments β-catenin signalingR-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signalingZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive mannerLGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressorInteraction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondinLGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signalingWnt modulators in the biotech pipelineWnt/beta-catenin signaling: components, mechanisms, and diseasesWnt signaling: the good and the badLGR4 and Its Role in Intestinal Protection and Energy MetabolismKeeping Wnt signalosome in check by vesicular trafficThe R-spondin protein familyCellular signaling and biological functions of R-spondinsStructural basis for R-spondin recognition by LGR4/5/6 receptorsCrystal Structures of Lgr4 and Its Complex with R-Spondin1Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondinWNT signaling in bone homeostasis and disease: from human mutations to treatmentsResearch progress in the radioprotective effect of the canonical Wnt pathwayRecombinant R-spondin2 and Wnt3a up- and down-regulate novel target genes in C57MG mouse mammary epithelial cellsR-spondins/Lgrs expression in tooth developmentWnt11 promotes osteoblast maturation and mineralization through R-spondin 2Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathwaysLmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/B-catenin signaling activator R-spondin 2N-Glycosylation of Human R-Spondin 1 Is Required for Efficient Secretion and Stability but Not for Its Heparin Binding AbilityTargeted disruption of the Wnt regulator Kremen induces limb defects and high bone densityIntrinsic disorder in spondins and some of their interacting partners.Wnt proteins.Neurodevelopment in schizophrenia: the role of the wnt pathways.R-spondin1 and FOXL2 act into two distinct cellular types during goat ovarian differentiation.Cloning and expression of R-Spondin1 in different vertebrates suggests a conserved role in ovarian developmentLrp4 modulates extracellular integration of cell signaling pathways in development.Protective role of R-spondin1, an intestinal stem cell growth factor, against radiation-induced gastrointestinal syndrome in mice.Loss-of-function point mutations and two-furin domain derivatives provide insights about R-spondin2 structure and function.To beta or not to beta: canonical beta-catenin signaling pathway and ovarian developmentMesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells.The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interactionComputational biophysical, biochemical, and evolutionary signature of human R-spondin family proteins, the member of canonical Wnt/β-catenin signaling pathway
P2860
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P248
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P2860
Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression
description
2006 nî lūn-bûn
@nan
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Mouse cristin/R-spondin family ...... enin-dependent gene expression
@ast
Mouse cristin/R-spondin family ...... enin-dependent gene expression
@en
Mouse cristin/R-spondin family ...... enin-dependent gene expression
@en-gb
Mouse cristin/R-spondin family ...... enin-dependent gene expression
@nl
type
label
Mouse cristin/R-spondin family ...... enin-dependent gene expression
@ast
Mouse cristin/R-spondin family ...... enin-dependent gene expression
@en
Mouse cristin/R-spondin family ...... enin-dependent gene expression
@en-gb
Mouse cristin/R-spondin family ...... enin-dependent gene expression
@nl
prefLabel
Mouse cristin/R-spondin family ...... enin-dependent gene expression
@ast
Mouse cristin/R-spondin family ...... enin-dependent gene expression
@en
Mouse cristin/R-spondin family ...... enin-dependent gene expression
@en-gb
Mouse cristin/R-spondin family ...... enin-dependent gene expression
@nl
P2093
P2860
P921
P3181
P356
P1476
Mouse cristin/R-spondin family ...... enin-dependent gene expression
@en
P2093
Jeong Kyo Yoon
Ju-Suk Nam
Peter F Smith
Sangdun Choi
Taryn J Turcotte
P2860
P304
P3181
P356
10.1074/JBC.M508324200
P407
P577
2006-05-12T00:00:00Z