R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
about
RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovaryHuman RSPO1/R-spondin1 is expressed during early ovary development and augments β-catenin signalingR-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signalingCaprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylationZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive mannerLGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressorInteraction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondinLGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signalingWnt/beta-catenin signaling: components, mechanisms, and diseasesLGR4 and Its Role in Intestinal Protection and Energy MetabolismKeeping Wnt signalosome in check by vesicular trafficGenetic polymorphism in extracellular regulators of Wnt signaling pathwayThe R-spondin protein familyCellular signaling and biological functions of R-spondinsBone marrow stromal cell transplantation mitigates radiation-induced gastrointestinal syndrome in miceThe structural basis of R-spondin recognition by LGR5 and RNF43Crystal Structures of Lgr4 and Its Complex with R-Spondin1Current understanding concerning intestinal stem cellsWNT signaling in bone homeostasis and disease: from human mutations to treatmentsAnalyzing the coordinated gene network underlying temperature-dependent sex determination in reptilesResearch progress in the radioprotective effect of the canonical Wnt pathwayRecombinant R-spondin2 and Wnt3a up- and down-regulate novel target genes in C57MG mouse mammary epithelial cellsThe Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineageWnt11 promotes osteoblast maturation and mineralization through R-spondin 2Kremen1 and Dickkopf1 control cell survival in a Wnt-independent mannerTargeted disruption of the Wnt regulator Kremen induces limb defects and high bone densityPaneth cells constitute the niche for Lgr5 stem cells in intestinal cryptsLef1 regulates Dusp6 to influence neuromast formation and spacing in the zebrafish posterior lateral line primordium.R-spondin1 and FOXL2 act into two distinct cellular types during goat ovarian differentiation.Cloning and expression of R-Spondin1 in different vertebrates suggests a conserved role in ovarian developmentCadherin-bound beta-catenin feeds into the Wnt pathway upon adherens junctions dissociation: evidence for an intersection between beta-catenin pools.Protective role of R-spondin1, an intestinal stem cell growth factor, against radiation-induced gastrointestinal syndrome in mice.A system-wide investigation of the dynamics of Wnt signaling reveals novel phases of transcriptional regulationNegative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2.Loss-of-function point mutations and two-furin domain derivatives provide insights about R-spondin2 structure and function.Differential modulation of TCF/LEF-1 activity by the soluble LRP6-ICD.To beta or not to beta: canonical beta-catenin signaling pathway and ovarian developmentA study on the interactions between heparan sulfate proteoglycans and Wnt proteins.Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells.
P2860
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P248
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P2860
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
description
2007 nî lūn-bûn
@nan
2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
@ast
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
@en
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
@en-gb
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
@nl
type
label
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
@ast
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
@en
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
@en-gb
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
@nl
prefLabel
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
@ast
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
@en
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
@en-gb
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
@nl
P2093
P2860
P921
P356
P1476
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
@en
P2093
Jason Williams
Jessica M Bright
John M Leung
Karolyn Tran
Kyung-Ah Kim
Marie Wagle
Melissa Dixon
Michael D Levy
P2860
P304
P356
10.1073/PNAS.0702305104
P407
P577
2007-09-11T00:00:00Z