Regulation of Sos activity by intramolecular interactions.
about
PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase RalOligomerization of DH domain is essential for Dbl-induced transformationGGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteinsActivation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activationA mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytesGrb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1Structural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange FactorsAnalysis of the role of the hypervariable region of yeast Ras2p and its farnesylation in the interaction with exchange factors and adenylyl cyclase.A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1APhosphorylation of the Ras-GRF1 exchange factor at Ser916/898 reveals activation of Ras signaling in the cerebral cortexAllostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner.The isoform-specific stretch of hSos1 defines a new Grb2-binding domain.One-way membrane trafficking of SOS in receptor-triggered Ras activation.Sites of phosphorylation by protein kinase A in CDC25Mm/GRF1, a guanine nucleotide exchange factor for Ras.Mechanism of SOS PR-domain autoinhibition revealed by single-molecule assays on native protein from lysate.Basis for the isoform-specific interaction of myosin phosphatase subunits protein phosphatase 1c beta and myosin phosphatase targeting subunit 1Allosteric gating of Son of sevenless activity by the histone domainActivation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504.Calmodulin-independent coordination of Ras and extracellular signal-regulated kinase activation by Ras-GRF2.Autoinhibition mechanism of proto-Dbl.Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless.A role for the noncatalytic N terminus in the function of Cdc25, a Saccharomyces cerevisiae Ras-guanine nucleotide exchange factor.Digital signaling and hysteresis characterize ras activation in lymphoid cells.SOS1 mutations in Noonan syndrome: molecular spectrum, structural insights on pathogenic effects, and genotype-phenotype correlationsAn activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the epidermal growth factor receptor pathway during Caenorhabditis elegans vulval development.Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif).Characterization of fibroblasts with Son of Sevenless-1 mutationMolecular mechanisms in signal transduction at the membrane.GEFs in growth factor signaling.Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells.Pairing computation with experimentation: a powerful coupling for understanding T cell signalling.Mammalian son of sevenless Guanine nucleotide exchange factors: old concepts and new perspectives.Approaches to Ras signaling modulation and treatment of Ras-dependent disorders: a patent review (2007--present).Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells.Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients.Analysis of mutations in the SOS-1 gene in two Polish families with hereditary gingival fibromatosis.New class of Son-of-sevenless (Sos) alleles highlights the complexities of Sos function.
P2860
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P2860
Regulation of Sos activity by intramolecular interactions.
description
1998 nî lūn-bûn
@nan
1998 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Regulation of Sos activity by intramolecular interactions
@nl
Regulation of Sos activity by intramolecular interactions.
@ast
Regulation of Sos activity by intramolecular interactions.
@en
Regulation of Sos activity by intramolecular interactions.
@en-gb
type
label
Regulation of Sos activity by intramolecular interactions
@nl
Regulation of Sos activity by intramolecular interactions.
@ast
Regulation of Sos activity by intramolecular interactions.
@en
Regulation of Sos activity by intramolecular interactions.
@en-gb
prefLabel
Regulation of Sos activity by intramolecular interactions
@nl
Regulation of Sos activity by intramolecular interactions.
@ast
Regulation of Sos activity by intramolecular interactions.
@en
Regulation of Sos activity by intramolecular interactions.
@en-gb
P2093
P2860
P356
P1476
Regulation of Sos activity by intramolecular interactions.
@en
P2093
D Bar-Sagi
S Corbalan-Garcia
S M Margarit
P2860
P304
P356
10.1128/MCB.18.2.880
P407
P577
1998-02-01T00:00:00Z