The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
about
Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinasehSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathwaysIdentification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase RalThe Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGFIdentification of 14-3-3zeta as an EGF receptor interacting proteinOligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteinsHierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptorSos-mediated activation of rac1 by p66shcThe phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptorSH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate mannerThe role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signalingMolecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cellsGrap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathwayA Ras-GTPase-activating protein SH3-domain-binding proteinGrowth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signalingIdentification of a novel polyproline recognition site in the cytoskeletal associated protein, proline serine threonine phosphatase interacting proteinDifferential interactions of human Sos1 and Sos2 with Grb2NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from SosSH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modulesBcr-Abl oncoproteins bind directly to activators of the Ras signalling pathwayRegulation of Sos activity by intramolecular interactions.A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domainsCloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targetsInduction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumorsRREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomasThe human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development.Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase.The structure and function of proline-rich regions in proteinsInteraction of Nck-associated protein 1 with activated GTP-binding protein RacThe beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesisSocs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferationDifferential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagementTyrosine phosphorylation regulates alpha II spectrin cleavage by calpainRecruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2
P2860
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P2860
The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
description
1993 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 1993
@ast
scientific journal article
@en
vedecký článok (publikovaný 1993/05/06)
@sk
vědecký článek publikovaný v roce 1993
@cs
wetenschappelijk artikel (gepubliceerd op 1993/05/06)
@nl
наукова стаття, опублікована в травні 1993
@uk
مقالة علمية (نشرت في 6-5-1993)
@ar
name
The SH2 and SH3 domains of mam ...... tor to the Ras activator mSos1
@ast
The SH2 and SH3 domains of mam ...... tor to the Ras activator mSos1
@en
The SH2 and SH3 domains of mam ...... tor to the Ras activator mSos1
@nl
type
label
The SH2 and SH3 domains of mam ...... tor to the Ras activator mSos1
@ast
The SH2 and SH3 domains of mam ...... tor to the Ras activator mSos1
@en
The SH2 and SH3 domains of mam ...... tor to the Ras activator mSos1
@nl
prefLabel
The SH2 and SH3 domains of mam ...... tor to the Ras activator mSos1
@ast
The SH2 and SH3 domains of mam ...... tor to the Ras activator mSos1
@en
The SH2 and SH3 domains of mam ...... tor to the Ras activator mSos1
@nl
P2093
P921
P3181
P356
P1433
P1476
The SH2 and SH3 domains of mam ...... tor to the Ras activator mSos1
@en
P2093
D. Bowtell
M. Rozakis-Adcock
R. Fernley
P2888
P3181
P356
10.1038/363083A0
P407
P50
P577
1993-05-06T00:00:00Z
P5875
P6179
1022031225