Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2
about
Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinasePhosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeletonPhosphorylation of the PTEN tail regulates protein stability and functionDeranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathyA method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domainThe serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaCThe tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells.Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3Identification of filamin C as a new physiological substrate of PKBalpha using KESTRELWNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substratePhosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivoThe PI3K-PDK1 connection: more than just a road to PKBPhosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expressionA phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stabilityProtein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)Importin-alpha mediates the regulated nuclear targeting of serum- and glucocorticoid-inducible protein kinase (Sgk) by recognition of a nuclear localization signal in the kinase central domainIdentification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKARegulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositidesAn amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinerySgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle.Akt isoforms in vascular diseasePerspectives in PDK1 evolution: insights from photosynthetic and non-photosynthetic organismsEthanol regulation of serum glucocorticoid kinase 1 expression in DBA2/J mouse prefrontal cortexProhibitin-mediated lifespan and mitochondrial stress implicate SGK-1, insulin/IGF and mTORC2 in C. elegansHigh resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site.Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity.SLI1 (YGR212W) is a major gene conferring resistance to the sphingolipid biosynthesis inhibitor ISP-1, and encodes an ISP-1 N-acetyltransferase in yeastYeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast.Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast.PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα InhibitionA 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoformsInhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase CRegulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivoThe PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.Impairment of mineralocorticoid receptor (MR)-dependent biological response by oxidative stress and aging: correlation with post-translational modification of MR and decreased ADP-ribosylatable level of elongating factor 2 in kidney cellsEssential role of PDK1 in regulating endothelial cell migrationA selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests
P2860
Q22010747-CE8C343B-984F-4D7F-BDA4-CBE477A2DE7FQ22254023-3FBDC733-1B9F-4B20-BDDF-A3D057DB7AE6Q22254305-200F01FD-913A-4447-84FC-023692BC15E8Q22254569-CC9E3ED8-7782-4FDD-BE1B-B9347682AC28Q24296738-33FB3399-E9F3-491F-AF88-BF11DE620592Q24297640-EE546EAF-6F63-4501-938D-8E0E45609BEDQ24301036-93324F55-FA28-4576-8768-EB45BDEA4659Q24528133-54B5C2A7-2B76-4FD3-9D18-3AC6EBAF7252Q24528134-2B760E4D-39FF-484D-BFCE-1A6AB1BFB53CQ24530650-ED771493-A127-4626-AAD0-3B1DEE346E88Q24531714-2F0BAC75-9E80-4A8E-AE9C-42534F4B2BD3Q24531972-6B9768B0-B022-4120-B213-09A9EC91B75DQ24534668-53A78196-F07F-4B36-8929-826F855386A5Q24534951-EAF8965E-1469-472B-8228-ED3252940D36Q24535623-A59BDFEA-99CB-4F10-ADC0-41CF3DECD4FFQ24551018-1CDA2D8A-133F-4F80-BF34-CE0B06533C67Q24554299-5A50194F-E865-45F7-AC23-132C7C58F1DFQ24600810-D1611A4B-91C6-43B1-A49D-CED4BDCB7CF7Q24669638-4CF195D6-9906-438E-99BE-2A3B39E0C2A6Q24676953-DCD13C02-03D1-475D-8BD2-DAE0CA579F50Q24816701-2A143676-766B-4E7D-A254-57E58E42B99FQ26851565-0D611504-9DC6-4703-A738-3877B5E71810Q26864397-AF5B243F-8FCC-4089-A71A-2328EB89B591Q27308641-EC797E78-1931-42D4-A147-D8F2ACFD3052Q27346904-BFC7B231-638A-462F-A497-37DFFD76C21BQ27639475-B16CE338-194F-4197-832C-86E6867D0201Q27930976-F06BD091-FA79-44A4-A7C4-6D4A35A8DCD7Q27933002-79CFEDDF-39DD-4B16-8A18-AE68B45254A2Q27934191-A7EEB2C0-BFA0-491D-A5E8-C01811FD2C53Q27934999-77C5CCD8-C6FD-4844-A428-ED83E9258C29Q28118735-D2B023C6-A32A-4E54-B731-D6B8B5DD6718Q28141738-1148447D-1747-4A48-9FA3-E2AAA8647FCCQ28205154-CF790F00-9D42-4F95-8AD9-295D4EF3C813Q28208351-E5E92B04-BDA1-45F5-836F-3EA93D1B44AAQ28217875-5ED94F99-A535-463A-917D-3C9A23B04A53Q28218728-E7AF01FF-32A7-4D02-B70F-6C7DCEDA8B1FQ28345841-8F49985A-838F-490B-9144-4D3C57EE62AAQ28506795-88D316AF-C385-4D93-B0A5-5C5C7BDFBA5DQ28509286-F99FC2E6-6AFE-417C-BD1D-D03B735B6B60Q28535325-F0D9485E-E710-4DCD-997E-6D6A6DC04ADD
P2860
Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Activation of serum- and gluco ...... otein kinase-1 (PDK1) and PDK2
@ast
Activation of serum- and gluco ...... otein kinase-1 (PDK1) and PDK2
@en
Activation of serum- and gluco ...... otein kinase-1 (PDK1) and PDK2
@en-gb
Activation of serum- and gluco ...... otein kinase-1 (PDK1) and PDK2
@nl
type
label
Activation of serum- and gluco ...... otein kinase-1 (PDK1) and PDK2
@ast
Activation of serum- and gluco ...... otein kinase-1 (PDK1) and PDK2
@en
Activation of serum- and gluco ...... otein kinase-1 (PDK1) and PDK2
@en-gb
Activation of serum- and gluco ...... otein kinase-1 (PDK1) and PDK2
@nl
prefLabel
Activation of serum- and gluco ...... otein kinase-1 (PDK1) and PDK2
@ast
Activation of serum- and gluco ...... otein kinase-1 (PDK1) and PDK2
@en
Activation of serum- and gluco ...... otein kinase-1 (PDK1) and PDK2
@en-gb
Activation of serum- and gluco ...... otein kinase-1 (PDK1) and PDK2
@nl
P2860
P3181
P1433
P1476
Activation of serum- and gluco ...... otein kinase-1 (PDK1) and PDK2
@en
P2093
P2860
P304
P3181
P356
10.1042/0264-6021:3390319
10.1042/BJ3390319
P407
P478
339 ( Pt 2)
P577
1999-04-15T00:00:00Z