Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT
about
Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motifSynergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domainsRecruitment and activation of PLCgamma1 in T cells: a new insight into old domainsNovel Src homology 3 domain-binding motifs identified from proteomic screen of a Pro-rich regionThe importance of three membrane-distal tyrosines in the adaptor protein NTAL/LABMolecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signalingSequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cellsRIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cellsPhosphoinositides: tiny lipids with giant impact on cell regulationRegulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zetaHematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytesThe phospholipase C isozymes and their regulationGPVI and integrin alphaIIb beta3 signaling in plateletsSLP76 and SLP65: complex regulation of signalling in lymphocytes and beyondPhosphorylation site dynamics of early T-cell receptor signalingA peptide-functionalized polymer as a minimal scaffold protein to enhance cluster formation in early T cell signal transduction.LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation.Competition between SLP76 and LAT for PLCγ1 binding in resting T cells.In vivo significance of ITK-SLP-76 interaction in cytokine production.Semaphorin 4D signaling requires the recruitment of phospholipase C gamma into the plexin-B1 receptor complex.Structural basis for recognition of the T cell adaptor protein SLP-76 by the SH3 domain of phospholipase Cgamma1Src homology domains in phospholipase C-gamma1 mediate its anti-apoptotic action through regulating the enzymatic activity.T cell receptor-induced activation of phospholipase C-gamma1 depends on a sequence-independent function of the P-I region of SLP-76.MIST functions through distinct domains in immunoreceptor signaling in the presence and absence of LAT.Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells.Persistence of cooperatively stabilized signaling clusters drives T-cell activationProteome analysis reveals caspase activation in hyporesponsive CD4 T lymphocytes induced in vivo by the oral administration of antigen.Molecular mechanisms underlying the evolution of the slp76 signalosome.Differential role of SLP-76 domains in T cell development and functionSpatial association of signaling proteins and F-actin effects on cluster assembly analyzed via photoactivation localization microscopy in T cellsThe nonphagocytic NADPH oxidase Duox1 mediates a positive feedback loop during T cell receptor signaling.A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function.The transmembrane adapter LAT plays a central role in immune receptor signalling.Quantitative phosphoproteomics reveals SLP-76 dependent regulation of PAG and Src family kinases in T cellsExamining multiprotein signaling complexes from all anglesT-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cellsPositive and negative regulation of T-cell activation by adaptor proteins.Regulation of B-cell signal transduction by adaptor proteins.Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cellsMutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.
P2860
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P2860
Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT
description
2001 nî lūn-bûn
@nan
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Identification of a phospholip ...... ivation of PLC-gamma1 and NFAT
@ast
Identification of a phospholip ...... ivation of PLC-gamma1 and NFAT
@en
Identification of a phospholip ...... ivation of PLC-gamma1 and NFAT
@nl
type
label
Identification of a phospholip ...... ivation of PLC-gamma1 and NFAT
@ast
Identification of a phospholip ...... ivation of PLC-gamma1 and NFAT
@en
Identification of a phospholip ...... ivation of PLC-gamma1 and NFAT
@nl
prefLabel
Identification of a phospholip ...... ivation of PLC-gamma1 and NFAT
@ast
Identification of a phospholip ...... ivation of PLC-gamma1 and NFAT
@en
Identification of a phospholip ...... ivation of PLC-gamma1 and NFAT
@nl
P2860
P1476
Identification of a phospholip ...... ivation of PLC-gamma1 and NFAT
@en
P2093
P2860
P304
P356
10.1128/MCB.21.13.4208-4218.2001
P407
P577
2001-07-01T00:00:00Z