Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation - sprookjes - yvandenbroek - TriplyDB

Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation

Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation

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Protein phosphatase 2A dysfunction in Alzheimer's disease Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model Therapeutic benefits of a component of coffee in a rat model of Alzheimer's disease.B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation Protein phosphatases and Alzheimer's disease Structure and function of the PP2A-shugoshin interaction PP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues.The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity The Beta-amyloid protein of Alzheimer's disease: communication breakdown by modifying the neuronal cytoskeleton PP1 and PP2A phosphatases--cooperating partners in modulating retinoblastoma protein activation Mechanisms of the scaffold subunit in facilitating protein phosphatase 2A methylation The Active Site of Oligogalacturonate Lyase Provides Unique Insights into Cytoplasmic Oligogalacturonate -Elimination Structure of the Ca2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation Structural and biochemical characterization of human PR70 in isolation and in complex with the scaffolding subunit of protein phosphatase 2A Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulation Identification of a mutation causing a defective spindle assembly checkpoint in high ethyl caproate-producing sake yeast strain K1801.Mechanisms of cancer cell killing by the adenovirus E4orf4 protein PP2A: The Wolf in Sheep's Clothing?NMR studies of the C-terminus of alpha4 reveal possible mechanism of its interaction with MID1 and protein phosphatase 2A Visualization of subunit interactions and ternary complexes of protein phosphatase 2A in mammalian cells Structure- and modeling-based identification of the adenovirus E4orf4 binding site in the protein phosphatase 2A B55α subunit The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation Striatins contain a noncanonical coiled coil that binds protein phosphatase 2A A subunit to form a 2:2 heterotetrameric core of striatin-interacting phosphatase and kinase (STRIPAK) complex.Interactome analysis of the influenza A virus transcription/replication machinery identifies protein phosphatase 6 as a cellular factor required for efficient virus replication.Mapping of protein phosphatase-6 association with its SAPS domain regulatory subunit using a model of helical repeats.Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.PR65, the HEAT-repeat scaffold of phosphatase PP2A, is an elastic connector that links force and catalysis Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation.Bioengineered protein phosphatase 2A: update on need Protein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progression Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation.Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau.Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice.The role of tau kinases in Alzheimer's disease.Loss of Hsp110 leads to age-dependent tau hyperphosphorylation and early accumulation of insoluble amyloid beta.Molecular determinants for PP2A substrate specificity: charged residues mediate dephosphorylation of tyrosine hydroxylase by the PP2A/B' regulatory subunit

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Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation

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2008 nî lūn-bûn

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2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2008年論文

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Structure of a Protein Phospha ...... Mediated Tau Dephosphorylation

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Structure of a Protein Phospha ...... Mediated Tau Dephosphorylation

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Structure of a Protein Phospha ...... Mediated Tau Dephosphorylation

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Structure of a Protein Phospha ...... Mediated Tau Dephosphorylation

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Structure of a Protein Phospha ...... Mediated Tau Dephosphorylation

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Structure of a Protein Phospha ...... Mediated Tau Dephosphorylation

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Structure of a Protein Phospha ...... Mediated Tau Dephosphorylation

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Structure of a Protein Phospha ...... Mediated Tau Dephosphorylation

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Philip D Jeffrey

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Ping Zhang

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Yanhui Xu

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Yu Chen

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P2860

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

A protein factor essential for microtubule assembly

Structure and mechanism of the phosphotyrosyl phosphatase activator

Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40

Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins

Structure of the protein phosphatase 2A holoenzyme

Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus

Carboxymethylation of nuclear protein serine/threonine phosphatase X

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits

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