Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta. - sprookjes - yvandenbroek - TriplyDB

Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.

Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.

http://www.wikidata.org/entity/Q30473576

about

Protein phosphatase 2A dysfunction in Alzheimer's disease Protein phosphatases and Alzheimer's disease The broken "Off" switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillance The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis The Basic Biology of PP2A in Hematologic Cells and Malignancies Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy Cloning and characterization of TaPP2AbB"-α, a member of the PP2A regulatory subunit in wheat Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau.γ-Aminobutyric acid type A (GABAA) receptor activation modulates tau phosphorylation.Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer.GSK3 and Alzheimer's Disease: Facts and Fiction….Sigma-1 receptor regulates Tau phosphorylation and axon extension by shaping p35 turnover via myristic acid.Cyclin-Dependent kinase 5 targeting prevents β-Amyloid aggregation involving glycogen synthase kinase 3β and phosphatases.B56δ-related protein phosphatase 2A dysfunction identified in patients with intellectual disability.B'-protein phosphatase 2A is a functional binding partner of delta-retroviral integrase.De novo missense variants in PPP2R5D are associated with intellectual disability, macrocephaly, hypotonia, and autism The importance of tau phosphorylation for neurodegenerative diseases PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice.Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease.Regulatory B Subunits of Protein Phosphatase 2A Are Involved in Site-specific Regulation of Tau Protein Phosphorylation.PP2A as a master regulator of the cell cycle.GSK-3β is Dephosphorylated by PP2A in a Leu309 Methylation-Independent Manner.PHD2 Targeting Overcomes Breast Cancer Cell Death upon Glucose Starvation in a PP2A/B55α-Mediated Manner.FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications.Atypical Protein Phosphatase 2A Gene Families Do Not Expand via Paleopolyploidization.Protein Phosphatase 2A: a Double-Faced Phosphatase of Cellular System and Its Role in Neurodegenerative Disorders.Glycogen synthase kinase-3β regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1.Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models.Nuclear life of the voltage-gated Cacnb4 subunit and its role in gene transcription regulation.ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase).APC/C-Cdh1 coordinates neurogenesis and cortical size during development.The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model.β-Adrenergic regulation of cardiac type 2A protein phosphatase through phosphorylation of regulatory subunit B56δ at S573.Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid.Protein phosphatase 2A and tau: an orchestrated 'Pas de Deux'.Loss of protein phosphatase 2A regulatory subunit B56δ promotes spontaneous tumorigenesis in vivo.Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β.A novel function of Ataxin-1 in the modulation of PP2A activity is dysregulated in the spinocerebellar ataxia type 1.Untangling Tau and Iron: Exploring the Interaction Between Iron and Tau in Neurodegeneration

P2860

Q21090465-02E75E32-8C40-42E3-80CA-A8B90DB43EC7 Q24632495-6FF016EF-499F-4518-B841-4ABF393FE601 Q26739246-9952C71C-B8AF-4DE9-84CC-4634D3411CB1 Q26824764-A28D1F1E-20BE-410F-8B3D-9057F8470A96 Q27310235-DCBA44E4-3B6F-4BD9-B0DD-E58D0375D113 Q28088697-B89AA1E2-B903-4529-BA80-65456BBB7840 Q28574061-21BD28DC-5044-4B03-B69D-4D012F13FDD0 Q31158092-882A5342-8A39-4D16-BF37-9FDCEEF4F2D1 Q33952539-E17C46D8-7A56-4E45-B046-10E7DE16D49A Q34123407-A4ADD4A2-1AB7-489F-B8CB-BF26158AFD66 Q34330600-CA566876-86E4-471C-90FF-3088ABBFA5A0 Q35182282-7F8095D6-49C4-41C6-AF8C-2C65BF108734 Q35669383-8DDF96BA-BB3D-4710-874B-E4DA76A3AC22 Q35772503-73D0C533-3941-4C84-B7E7-07DAEFC0CDFA Q36216530-BF8D997D-BD3B-44B4-AD78-7CA7611DEA9A Q36443322-CEDFBF95-0E3B-477B-9F26-E2D78EF21E51 Q36612951-B523784B-0303-4A05-B6DE-A5F3B2A0C4A5 Q36968220-AA770FD7-4ACD-42B9-9FA5-1CBE2387ACC7 Q37186184-9B60E79C-524E-47C3-A774-86FFDF43F85F Q37441782-722585B0-E775-46E7-AED1-ABEA98F032F5 Q37714629-8ED6142C-8B23-4EB5-9B7D-1F3C153CB10E Q38746849-AD1B5C8D-8855-4CF8-ACD3-8C105156E07B Q38826441-624B3222-D208-4567-82C6-D40F04C97787 Q38886150-84B6D3BE-F339-48FB-ABFC-E10817E81905 Q38890067-E3EEB353-5AB7-439C-AD24-B0C1816014A9 Q39051864-CE0D1D26-B196-42E6-8030-16D359816265 Q39146231-C23397BD-6821-40C7-AEE1-B041ACB56277 Q39325433-95EA045C-AA95-42F3-92EC-1DA06BFB1BA6 Q39994322-5E2DE9D1-4378-478E-A711-2B97FEB5F657 Q41217397-659447FB-A987-45D5-9013-44EE65D0D980 Q41784558-80D0CF95-85CD-41AB-9E9B-0D5241705AC7 Q41930994-0E8F9D21-B4E0-422B-976D-84B7A73DDA97 Q47137224-1148BC6B-13F9-4D3D-8DFB-33E6F9B82936 Q47237804-00AF3F75-A119-472D-ACCF-B5C9415558E7 Q47279111-BDDE9981-8C09-4389-8447-4E7BA2160549 Q47420946-85FB2029-F404-4D4F-9C5E-C20553A98EE7 Q47716673-FE592058-C97D-445C-B50E-128B55C936F1 Q47880863-D170A198-2A33-4D7B-9566-C3B3F2EF9168 Q51030072-E52014B8-39C7-4FC5-9160-B2EB04A967C3 Q58769184-9D2B07A9-40F1-4750-AB32-834946633597

P2860

Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.

http://www.wikidata.org/entity/Q30473576

description

2011 nî lūn-bûn

@nan

2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Mice lacking phosphatase PP2A ...... gulation of CDK5 and GSK3beta.

@ast

Mice lacking phosphatase PP2A ...... gulation of CDK5 and GSK3beta.

@en

type

label

Mice lacking phosphatase PP2A ...... gulation of CDK5 and GSK3beta.

@ast

Mice lacking phosphatase PP2A ...... gulation of CDK5 and GSK3beta.

@en

prefLabel

Mice lacking phosphatase PP2A ...... gulation of CDK5 and GSK3beta.

@ast

Mice lacking phosphatase PP2A ...... gulation of CDK5 and GSK3beta.

@en

P1433

Q30473576-4BE11B48-8E93-47C8-B34E-D63595274E06

P1476

Q30473576-4D0E01DF-4DA2-4DAB-B2CA-D2934B862613

P2093

Q30473576-092A13A1-99CE-47A0-80A6-D98119BE451C

Q30473576-1606C804-1257-4355-A863-61028B5BC869

Q30473576-27256133-8D29-46F6-B7F8-ADC21559ECB1

Q30473576-584FCBD6-A59B-4DE2-BDA9-D8154D001FC9

Q30473576-627A2480-E261-4687-BFBC-F9BB7FBD9FAB

Q30473576-788772CE-72DF-4F51-B6A0-8539D30DE76D

Q30473576-8B4B96F5-06EF-4183-9CD6-D0CE3139C2D4

Q30473576-8EDA8FDE-5612-453F-A108-7D5583F8F2BA

Q30473576-D355CA22-4E0D-4967-AEC6-53527B71999C

Q30473576-DD0E31CB-EDE3-446C-83DE-F2030F5B845C

P2860

Q30473576-0B153DC6-E6FE-4EA0-B2C9-0E116AB06417

Q30473576-0B19DF34-1D42-45EA-95E8-BDCD08DC59F2

Q30473576-0B9223E3-1DDF-4705-A4AF-2BF789EEFCC7

Q30473576-11AD3A58-FF97-45E5-ABA5-AE9D849C5725

Q30473576-12203025-592C-4663-97A6-336CF9AB46B1

Q30473576-16035144-CEBA-49F1-BE3B-FB8F7276A663

Q30473576-184F54A1-35A2-4C53-A75F-707AAC5EBFBE

Q30473576-1A26A4FB-1F3E-43F8-8807-440B47E37F00

Q30473576-1CAE249E-6C26-49B8-A3D0-EBFC6754CC80

Q30473576-1EF8424F-9822-4727-857F-0C69F627FB7F

P304

Q30473576-B412C935-6507-4507-BCB0-B792BF08B314

P31

Q30473576-AD50C824-3343-4395-8C19-D0CF3F1355F5

P356

Q30473576-F389885F-07FD-4766-9273-8B0545E7DE91

P407

Q30473576-404C7991-259B-49D0-B448-6F87E64A003B

P433

Q30473576-268E2307-3D32-445A-A879-A0258FBF5A54

P478

Q30473576-96D17306-242B-494D-9560-9B1971D7B048

P50

Q30473576-009E1798-2775-4D1F-A292-B0A4C896664C

Q30473576-07BDCCDC-55D6-4222-B7ED-E11093740832

Q30473576-103271C7-E63F-4E09-BE94-981DD0BE3C00

Q30473576-D07D0220-C7B8-4DE8-8D2F-1178F3879B55

P577

Q30473576-5DFEA0EA-B30A-4FA5-B0DA-2F294EEB8786

P5875

Q30473576-1B0C8C11-05F4-4E49-B7C2-2BEAB862B553

P698

Q30473576-B0DA7383-594D-43A9-8F15-114FBAF320B0

P932

Q30473576-004D94E6-AFCD-45CE-96F3-4C9B117D5A04

P356

PNAS.1018777108

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Mice lacking phosphatase PP2A ...... gulation of CDK5 and GSK3beta.

@en

P2093

Birgit Ledermann

http://www.w3.org/2001/XMLSchema#string

Caroline Lambrecht

http://www.w3.org/2001/XMLSchema#string

Ellen Martens

http://www.w3.org/2001/XMLSchema#string

Jozef Goris

http://www.w3.org/2001/XMLSchema#string

Justin V Louis

http://www.w3.org/2001/XMLSchema#string

Karen Zwaenepoel

http://www.w3.org/2001/XMLSchema#string

Peter Borghgraef

http://www.w3.org/2001/XMLSchema#string

Robert Pijnenborg

http://www.w3.org/2001/XMLSchema#string

Sari Longin

http://www.w3.org/2001/XMLSchema#string

Ward Sents

http://www.w3.org/2001/XMLSchema#string

P2860

The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm

Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation

Neurotoxicity induces cleavage of p35 to p25 by calpain

PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation

p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]

Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha

A phosphatase cascade by which rewarding stimuli control nucleosomal response.

The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

P304

6957-6962

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.1018777108

http://www.w3.org/2001/XMLSchema#string

P407

P433

17

http://www.w3.org/2001/XMLSchema#string

P478

108

http://www.w3.org/2001/XMLSchema#string

P50

Veerle Janssens

Isabelle Landrieu

P577

2011-04-11T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

235607786

http://www.w3.org/2001/XMLSchema#string

P698

21482799

http://www.w3.org/2001/XMLSchema#string

P932

3084077

http://www.w3.org/2001/XMLSchema#string