Crystal structure of the adenylyl cyclase activator Gsalpha
about
Ser/ Thr residues at α3/β5 loop of Gαs are important in morphine-induced adenylyl cyclase sensitization but not mitogen-activated protein kinase phosphorylationA novel mutation in the switch 3 region of Gsalpha in a patient with Albright hereditary osteodystrophy impairs GDP binding and receptor activationGalpha i3 binding to calnuc on Golgi membranes in living cells monitored by fluorescence resonance energy transfer of green fluorescent protein fusion proteinsCrystal structure of the β2 adrenergic receptor-Gs protein complexThe structural basis of arrestin-mediated regulation of G-protein-coupled receptorsCharacterization of subcellular localization and stability of a splice variant of G alpha i2A new way to rapidly create functional, fluorescent fusion proteins: random insertion of GFP with an in vitro transposition reactionSignal activation and inactivation by the Gα helical domain: a long-neglected partner in G protein signalingComputational Simulation of the Activation Cycle of Gα Subunit in the G Protein Cycle Using an Elastic Network ModelStructural basis for self-association and receptor recognition of human TRAF2Structure of Gialpha1.GppNHp, autoinhibition in a galpha protein-substrate complexStructural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognitionMolecular architecture of G o and the structural basis for RGS16-mediated deactivationA Constitutively Active Gα Subunit Provides Insights into the Mechanism of G Protein ActivationGenetic analysis of the Drosophila Gs(alpha) geneEffects of G-protein mutations on skin colorNullspace Sampling with Holonomic Constraints Reveals Molecular Mechanisms of Protein GαsRegulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VIIActivated alleles of the Schizosaccharomyces pombe gpa2+ Galpha gene identify residues involved in GDP-GTP exchange.Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at WorkA molecular and structural mechanism for G protein-mediated microtubule destabilization.Conformational biosensors reveal GPCR signalling from endosomes.Conformational studies on a synthetic C-terminal fragment of the alpha subunit of G(S) proteins.Selective resistance to parathyroid hormone caused by a novel uncoupling mutation in the carboxyl terminus of G alpha(s). A cause of pseudohypoparathyroidism type Ib.Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchangeEvolution of class-specific peptides targeting a hot spot of the Galphas subunit.Membrane Guanylate Cyclase catalytic Subdomain: Structure and Linkage with Calcium Sensors and BicarbonateA structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration.Different biochemical properties explain why two equivalent Gα subunit mutants cause unrelated diseasesEvolution of a signaling nexus constrained by protein interfaces and conformational States.Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein alpha-subunit.Active-state models of ternary GPCR complexes: determinants of selective receptor-G-protein coupling.Calnuc, an EF-hand Ca(2+) binding protein, specifically interacts with the C-terminal alpha5-helix of G(alpha)i3.Functional characterization of GNAS mutations found in patients with pseudohypoparathyroidism type Ic defines a new subgroup of pseudohypoparathyroidism affecting selectively Gsα-receptor interaction.A mutation in the heterotrimeric stimulatory guanine nucleotide binding protein alpha-subunit with impaired receptor-mediated activation because of elevated GTPase activity.Identification of a novel mutation in a pseudohypoparathyroidism familyThe extreme C-terminal region of Gαs differentially couples to the luteinizing hormone and beta2-adrenergic receptors.A positive genotype-phenotype correlation in a large cohort of patients with Pseudohypoparathyroidism Type Ia and Pseudo-pseudohypoparathyroidism and 33 newly identified mutations in the GNAS geneStructural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex.Structural features of parathyroid hormone receptor coupled to Galpha(s)-protein.
P2860
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P2860
Crystal structure of the adenylyl cyclase activator Gsalpha
description
1997 nî lūn-bûn
@nan
1997 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
Crystal structure of the adenylyl cyclase activator Gsalpha
@ast
Crystal structure of the adenylyl cyclase activator Gsalpha
@en
Crystal structure of the adenylyl cyclase activator Gsalpha
@nl
type
label
Crystal structure of the adenylyl cyclase activator Gsalpha
@ast
Crystal structure of the adenylyl cyclase activator Gsalpha
@en
Crystal structure of the adenylyl cyclase activator Gsalpha
@nl
prefLabel
Crystal structure of the adenylyl cyclase activator Gsalpha
@ast
Crystal structure of the adenylyl cyclase activator Gsalpha
@en
Crystal structure of the adenylyl cyclase activator Gsalpha
@nl
P2093
P3181
P1433
P1476
Crystal structure of the adenylyl cyclase activator Gsalpha
@en
P2093
A G Gilman
R K Sunahara
S R Sprang
P304
P3181
P356
10.1126/SCIENCE.278.5345.1943
P407
P50
P577
1997-12-01T00:00:00Z