The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues
about
Multiple viral ligands naturally presented by different class I molecules in transporter antigen processing-deficient vaccinia virus-infected cellsMajor histocompatibility complex class I molecules expressed with monoglucosylated N-linked glycans bind calreticulin independently of their assembly statusHLA-B27 and psoriatic disease: a modern view of an old relationshipIntracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-PresentationAlternative Antigen Processing for MHC Class I: Multiple Roads Lead to RomeMechanisms of HIV protein degradation into epitopes: implications for vaccine designAntigenic peptide trimming by ER aminopeptidases--insights from structural studiesEndoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune responseHepatitis C virus and ethanol alter antigen presentation in liver cellsWhat is the role of alternate splicing in antigen presentation by major histocompatibility complex class I molecules?Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimmingA Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen ProcessingStructural insights into the molecular ruler mechanism of the endoplasmic reticulum aminopeptidase ERAP1Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responsesFrom HLA-B27 to spondyloarthritis: a journey through the ER.Antigen Presentation, Autoantigens, and Immune Regulation in Multiple Sclerosis and Other Autoimmune DiseasesERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulumRequirement of the proteasome for the trimming of signal peptide-derived epitopes presented by the nonclassical major histocompatibility complex class I molecule HLA-EDistribution of adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase (ERAP)-1 in human uterine endometriumA genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.Identification of an alternate splice form of tapasin in human melanoma.An endogenous HIV envelope-derived peptide without the terminal NH3+ group anchor is physiologically presented by major histocompatibility complex class I molecules.Two HLA-B14 subtypes (B*1402 and B*1403) differentially associated with ankylosing spondylitis differ substantially in peptide specificity but have limited peptide and T-cell epitope sharing with HLA-B27.Extracellular TNFR1 release requires the calcium-dependent formation of a nucleobindin 2-ARTS-1 complex.EpiJen: a server for multistep T cell epitope prediction.Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradationThe internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.Impaired methylation as a novel mechanism for proteasome suppression in liver cellsERAP1 reduces accumulation of aberrant and disulfide-linked forms of HLA-B27 on the cell surfaceCutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzymeHeat shock protein and gliadin peptide promote development of peptidase antibodies in children with autism and patients with autoimmune disease.Escape mutations alter proteasome processing of major histocompatibility complex class I-restricted epitopes in persistent hepatitis C virus infection.Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation.Manipulation of EAT-2 expression promotes induction of multiple beneficial regulatory and effector functions of the human innate immune system as a novel immunomodulatory strategyThe specificity of trimming of MHC class I-presented peptides in the endoplasmic reticulum.Characterizing the specificity and cooperation of aminopeptidases in the cytosol and endoplasmic reticulum during MHC class I antigen presentationOvalbumin-derived precursor peptides are transferred sequentially from gp96 and calreticulin to MHC class I in the endoplasmic reticulum.Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1
P2860
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P2860
The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues
description
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
scientific journal article
@en
vedecký článok (publikovaný 2002/12/01)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/12/01)
@nl
wissenschaftlicher Artikel
@de
наукова стаття, опублікована в грудні 2002
@uk
مقالة علمية (نشرت في ديسمبر 2002)
@ar
name
The ER aminopeptidase ERAP1 en ...... mming epitopes to 8-9 residues
@ast
The ER aminopeptidase ERAP1 en ...... mming epitopes to 8-9 residues
@en
The ER aminopeptidase ERAP1 en ...... mming epitopes to 8-9 residues
@nl
type
label
The ER aminopeptidase ERAP1 en ...... mming epitopes to 8-9 residues
@ast
The ER aminopeptidase ERAP1 en ...... mming epitopes to 8-9 residues
@en
The ER aminopeptidase ERAP1 en ...... mming epitopes to 8-9 residues
@nl
prefLabel
The ER aminopeptidase ERAP1 en ...... mming epitopes to 8-9 residues
@ast
The ER aminopeptidase ERAP1 en ...... mming epitopes to 8-9 residues
@en
The ER aminopeptidase ERAP1 en ...... mming epitopes to 8-9 residues
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
The ER aminopeptidase ERAP1 en ...... mming epitopes to 8-9 residues
@en
P2093
Alfred L Goldberg
Janice M Favreau
Jennifer A Keys
Kenneth L Rock
P2860
P304
P3181
P356
10.1038/NI860
P407
P577
2002-11-18T00:00:00Z