Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway - sprookjes - yvandenbroek - TriplyDB

Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway

Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway

http://www.wikidata.org/entity/Q28116174

about

KRIT1 regulates the homeostasis of intracellular reactive oxygen species Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stress Loss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformations Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling.Zebrafish as an Emerging Model Organism to Study Angiogenesis in Development and Regeneration Cerebral cavernous malformation is a vascular disease associated with activated RhoA signaling Molecular mechanisms controlling vascular lumen formation in three-dimensional extracellular matrices Endothelial cell-cell adhesion during zebrafish vascular development Cdc42 and k-Ras Control Endothelial Tubulogenesis through Apical Membrane and Cytoskeletal Polarization: Novel Stimulatory Roles for GTPase Effectors, the Small GTPases, Rac2 and Rap1b, and Inhibitory Influence of Arhgap31 and Rasa1 Micro-CT Imaging Reveals Mekk3 Heterozygosity Prevents Cerebral Cavernous Malformations in Ccm2-Deficient Mice Ve-ptp modulates vascular integrity by promoting adherens junction maturation Structural basis of the junctional anchorage of the cerebral cavernous malformations complex Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation The Structure of the Ternary Complex of Krev Interaction Trapped 1 (KRIT1) Bound to Both the Rap1 GTPase and the Heart of Glass (HEG1) Cytoplasmic Tail Structural Basis for Small G Protein Effector Interaction of Ras-related Protein 1 (Rap1) and Adaptor Protein Krev Interaction Trapped 1 (KRIT1)Structural Determinants for Binding of Sorting Nexin 17 (SNX17) to the Cytoplasmic Adaptor Protein Krev Interaction Trapped 1 (KRIT1)Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype.Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth Structural basis for the disruption of the cerebral cavernous malformations 2 (CCM2) interaction with Krev interaction trapped 1 (KRIT1) by disease-associated mutations Phosphorylation sites in the cerebral cavernous malformations complex Rap1 and its effector KRIT1/CCM1 regulate beta-catenin signaling.CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations CCM1-ICAP-1 complex controls β1 integrin-dependent endothelial contractility and fibronectin remodeling Regulatory mechanisms of testosterone-stimulated song in the sensorimotor nucleus HVC of female songbirds.Dynamic contrast-enhanced MRI evaluation of cerebral cavernous malformations.HEG1 is a novel mucin-like membrane protein that serves as a diagnostic and therapeutic target for malignant mesothelioma.Recent insights into cerebral cavernous malformations: a complex jigsaw puzzle under construction.Biology of vascular malformations of the brain.Control of cell adhesion dynamics by Rap1 signaling.Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity.Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype Mechanisms of vascular stability and the relationship to human disease Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development Loss of cerebral cavernous malformation 3 (Ccm3) in neuroglia leads to CCM and vascular pathology.ccm2-like is required for cardiovascular development as a novel component of the Heg-CCM pathway.A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions.Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations.Genetics of cerebral cavernous malformations: current status and future prospects Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature.Crystallization and preliminary X-ray analysis of the C-terminal domain of CCM2, part of a novel adaptor protein involved in cerebral cavernous malformations.

P2860

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P2860

Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway

http://www.wikidata.org/entity/Q28116174

description

2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2009

@ast

im Februar 2009 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2009/02/01)

@sk

vědecký článek publikovaný v roce 2009

@cs

wetenschappelijk artikel (gepubliceerd op 2009/02/01)

@nl

наукова стаття, опублікована в лютому 2009

@uk

مقالة علمية (نشرت في فبراير 2009)

@ar

name

Regulation of cardiovascular d ...... s malformation protein pathway

@ast

Regulation of cardiovascular d ...... s malformation protein pathway

@en

Regulation of cardiovascular d ...... s malformation protein pathway

@nl

type

label

Regulation of cardiovascular d ...... s malformation protein pathway

@ast

Regulation of cardiovascular d ...... s malformation protein pathway

@en

Regulation of cardiovascular d ...... s malformation protein pathway

@nl

prefLabel

Regulation of cardiovascular d ...... s malformation protein pathway

@ast

Regulation of cardiovascular d ...... s malformation protein pathway

@en

Regulation of cardiovascular d ...... s malformation protein pathway

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P1433

Nature Medicine

P1476

Regulation of cardiovascular d ...... s malformation protein pathway

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P2093

Benjamin Kleaveland

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Diane Zhou

http://www.w3.org/2001/XMLSchema#string

Jan Kitajewski

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Jennifer J. Tung

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Jian J. Liu

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Lili Guo

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Mark H. Ginsberg

http://www.w3.org/2001/XMLSchema#string

Mark L. Kahn

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Mei Chen

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Min-min Lu

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P2860

Mutations within the MGC4607 gene cause cerebral cavernous malformations

CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis

CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations

Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations

Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations.

KRIT1 is mutated in hyperkeratotic cutaneous capillary-venous malformation associated with cerebral capillary malformation

Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1)

KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions

In vivo imaging of embryonic vascular development using transgenic zebrafish

A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos

P2888

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169–176

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scholarly article

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4001997

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10.1038/NM.1918

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2

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15

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Markus Affolter

Xiangjian Zheng

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2009-02-01T00:00:00Z

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23798823

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19151727

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P921

Aparato circulatorio

endothelial tube morphogenesis

Catenin (cadherin associated protein), beta 1

CCM2 scaffold protein

Cerebral cavernous malformation 2

Heart development protein with EGF-like domains 1

KRIT1, ankyrin repeat containing

P932

2665266

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