The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors
about
SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactomeSLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activityFunctional association between SLAP-130 and SLP-76 in Jurkat T cellsAssociation of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signalingProtein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylationEfficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motifNovel Src homology 3 domain-binding motifs identified from proteomic screen of a Pro-rich regionThe importance of three membrane-distal tyrosines in the adaptor protein NTAL/LABMolecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signalingSequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cellsLAB: a new membrane-associated adaptor molecule in B cell activationA PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT.Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation.Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling.Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFATT cell activationLIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activationGrf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LATGrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activationStructural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascadeInteraction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxinRegulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zetaShb links SLP-76 and Vav with the CD3 complex in Jurkat T cellsLAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathwaysLeukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytesThe C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motifAssociation of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinaseSLP76 and SLP65: complex regulation of signalling in lymphocytes and beyondXB130: A novel adaptor protein in cancer signal transductionIdentification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cellsClnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cellsPhosphorylation site dynamics of early T-cell receptor signalingHematopoietic adaptors in T-cell signaling: potential applications to transplantationExpression of GADS enhances FLT3-induced mitogenic signaling.A peptide-functionalized polymer as a minimal scaffold protein to enhance cluster formation in early T cell signal transduction.Competition between SLP76 and LAT for PLCγ1 binding in resting T cells.In vivo significance of ITK-SLP-76 interaction in cytokine production.Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76.T cell receptor-induced activation of phospholipase C-gamma1 depends on a sequence-independent function of the P-I region of SLP-76.
P2860
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P2860
The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The hematopoietic-specific ada ...... th the SLP-76 and LAT adaptors
@ast
The hematopoietic-specific ada ...... th the SLP-76 and LAT adaptors
@en
The hematopoietic-specific ada ...... th the SLP-76 and LAT adaptors
@nl
type
label
The hematopoietic-specific ada ...... th the SLP-76 and LAT adaptors
@ast
The hematopoietic-specific ada ...... th the SLP-76 and LAT adaptors
@en
The hematopoietic-specific ada ...... th the SLP-76 and LAT adaptors
@nl
prefLabel
The hematopoietic-specific ada ...... th the SLP-76 and LAT adaptors
@ast
The hematopoietic-specific ada ...... th the SLP-76 and LAT adaptors
@en
The hematopoietic-specific ada ...... th the SLP-76 and LAT adaptors
@nl
P2093
P1433
P1476
The hematopoietic-specific ada ...... th the SLP-76 and LAT adaptors
@en
P2093
P356
10.1016/S0960-9822(99)80017-7
P407
P577
1999-01-01T00:00:00Z