p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]
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The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKRRegulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegenerationProtein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signallingTemperature and toxic Tau in Alzheimer's disease: new insightsPropofol directly increases tau phosphorylationCytoskeletal pathologies of Alzheimer diseaseMice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.Tau pathology generated by overexpression of tau.Sevoflurane induces tau phosphorylation and glycogen synthase kinase 3β activation in young miceDimethyl sulfoxide induces both direct and indirect tau hyperphosphorylation.Protein phosphatase 2A1 is the major enzyme in vertebrate cell extracts that dephosphorylates several physiological substrates for cyclin-dependent protein kinases.Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease.Molecular Cloning of the Genes Encoding the PR55/Bβ/δ Regulatory Subunits for PP-2A and Analysis of Their Functions in Regulating Development of Goldfish, Carassius auratus.Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathiesIs hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation.Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiencyOkadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease.Paired helical filament tau in Alzheimer's disease. The kinase connection.Selective tau tyrosine nitration in non-AD tauopathies.Altered regulation of tau phosphorylation in a mouse model of down syndrome agingNicotinic Acetylcholine Receptors Sensitize a MAPK-linked Toxicity Pathway on Prolonged Exposure to β-Amyloid.Mitotic mechanisms in Alzheimer's disease?The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.Anesthesia and tau pathology.Rapid induction of intraneuronal neurofibrillary tangles in apolipoprotein E-deficient mice.Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cellsCalcineurin is associated with the cytoskeleton of cultured neurons and has a role in the acquisition of polarity.The pool of map kinase associated with microtubules is small but constitutively activeUse of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases.Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau.Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer's Disease.Inhibition of JNK by a peptide inhibitor reduces traumatic brain injury-induced tauopathy in transgenic miceSomatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform.Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356.Modulation of the phosphorylation state of tau in situ: the roles of calcium and cyclic AMP.Cortical and brainstem-type Lewy bodies are immunoreactive for the cyclin-dependent kinase 5Selective stabilization of tau in axons and microtubule-associated protein 2C in cell bodies and dendrites contributes to polarized localization of cytoskeletal proteins in mature neurons.
P2860
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P2860
p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]
description
1992 nî lūn-bûn
@nan
1992 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
p42 MAP kinase phosphorylation ...... lzheimer's disease [corrected]
@ast
p42 MAP kinase phosphorylation ...... lzheimer's disease [corrected]
@en
p42 MAP kinase phosphorylation ...... lzheimer's disease [corrected]
@nl
type
label
p42 MAP kinase phosphorylation ...... lzheimer's disease [corrected]
@ast
p42 MAP kinase phosphorylation ...... lzheimer's disease [corrected]
@en
p42 MAP kinase phosphorylation ...... lzheimer's disease [corrected]
@nl
prefLabel
p42 MAP kinase phosphorylation ...... lzheimer's disease [corrected]
@ast
p42 MAP kinase phosphorylation ...... lzheimer's disease [corrected]
@en
p42 MAP kinase phosphorylation ...... lzheimer's disease [corrected]
@nl
P2093
P921
P1433
P1476
p42 MAP kinase phosphorylation ...... lzheimer's disease [corrected]
@en
P2093
P407
P577
1992-11-02T00:00:00Z