ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation.
about
Function, regulation and pathological roles of the Gab/DOS docking proteinsAdaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cellsNew role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survivalMET: a critical player in tumorigenesis and therapeutic targetThe role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptorsInteraction domains: from simple binding events to complex cellular behaviorShcA tyrosine phosphorylation sites can replace ShcA binding in signalling by middle T-antigenAngiomotin regulates endothelial cell migration during embryonic angiogenesisShcA signalling is essential for tumour progression in mouse models of human breast cancerThe fibronectin leucine-rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesisA Transformation-Defective Polyomavirus Middle T Antigen with a Novel Defect in PI3 Kinase Signaling.Shp2 suppresses PyMT-induced transformation in mouse fibroblasts by inhibiting Stat3 activity.Membrane targeting of Grb2-associated binder-1 (Gab1) scaffolding protein through Src myristoylation sequence substitutes for Gab1 pleckstrin homology domain and switches an epidermal growth factor response to an invasive morphogenic program.Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens.Lessons in signaling and tumorigenesis from polyomavirus middle T antigen.Gab1 is required for cell cycle transition, cell proliferation, and transformation induced by an oncogenic met receptor.Independent contributions of polyomavirus middle T and small T to the regulation of early and late gene expression and DNA replicationSH2 and PTB domains in tyrosine kinase signaling.A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site.P-selectin activates integrin-mediated colon carcinoma cell adhesion to fibronectinGrb2 monomer-dimer equilibrium determines normal versus oncogenic function.The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesisLessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer.Generation of an immortalized murine brain microvascular endothelial cell line as an in vitro blood brain barrier model.Shc and the mechanotransduction of cellular anchorage and metastasis.The p110alpha isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation.The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma.p66Shc couples mechanical signals to RhoA through FAK-dependent recruitment of p115-RhoGEF and GEF-H1.Insights into the Shc Family of Adaptor Proteins.Imatinib mesylate inhibits proliferation of rheumatoid synovial fibroblast-like cells and phosphorylation of Gab adapter proteins activated by platelet-derived growth factor.Contributions of the RhoA guanine nucleotide exchange factor Net1 to polyoma middle T antigen-mediated mammary gland tumorigenesis and metastasis.
P2860
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P2860
ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation.
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
ShcA and Grb2 mediate polyoma ...... Gab1 tyrosine phosphorylation
@nl
ShcA and Grb2 mediate polyoma ...... Gab1 tyrosine phosphorylation.
@ast
ShcA and Grb2 mediate polyoma ...... Gab1 tyrosine phosphorylation.
@en
type
label
ShcA and Grb2 mediate polyoma ...... Gab1 tyrosine phosphorylation
@nl
ShcA and Grb2 mediate polyoma ...... Gab1 tyrosine phosphorylation.
@ast
ShcA and Grb2 mediate polyoma ...... Gab1 tyrosine phosphorylation.
@en
prefLabel
ShcA and Grb2 mediate polyoma ...... Gab1 tyrosine phosphorylation
@nl
ShcA and Grb2 mediate polyoma ...... Gab1 tyrosine phosphorylation.
@ast
ShcA and Grb2 mediate polyoma ...... Gab1 tyrosine phosphorylation.
@en
P2093
P2860
P356
P1433
P1476
ShcA and Grb2 mediate polyoma ...... Gab1 tyrosine phosphorylation.
@en
P2093
I Hauck-Schmalenberger
S Dilworth
P2860
P304
P356
10.1093/EMBOJ/20.22.6327
P407
P577
2001-11-01T00:00:00Z