Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development
about
Regulation of TGF-β signal transduction by mono- and deubiquitylation of SmadsFunctions of the 19S complex in proteasomal degradationStructural characterization of human Uch37Evolution of proteasome regulators in eukaryotesA novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistanceCharacterisation of the Trichinella spiralis deubiquitinating enzyme, TsUCH37, an evolutionarily conserved proteasome interaction partnerAn optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes.Structural basis for the activation and inhibition of the UCH37 deubiquitylase.Balancing act: deubiquitinating enzymes in the nervous system.Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis.Ubiquitin pathway and ovarian cancer.Amplification Target ADRM1: Role as an Oncogene and Therapeutic Target for Ovarian Cancer.Structural insights into proteasome activation by the 19S regulatory particle.A bis-benzylidine piperidone targeting proteasome ubiquitin receptor RPN13/ADRM1 as a therapy for cancer.Role of the ubiquitin-proteasome system in nervous system function and disease: using C. elegans as a dissecting tool.Deubiquitylases from genes to organism.Distinct Molecular Signature of Murine Fetal Liver and Adult Hematopoietic Stem Cells Identify Novel Regulators of Hematopoietic Stem Cell Function.A reversible and highly selective inhibitor of the proteasomal ubiquitin receptor rpn13 is toxic to multiple myeloma cellsKnockdown of ovarian cancer amplification target ADRM1 leads to downregulation of GIPC1 and upregulation of RECK.Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G.Polyubiquitinated proteins, proteasome, and glycogen characterize the particle-rich cytoplasmic structure (PaCS) of neoplastic and fetal cells.The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome.Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11.High expression of UCH37 is significantly associated with poor prognosis in human epithelial ovarian cancer.Meddling with Fate: The Proteasomal Deubiquitinating Enzymes.UCHL5 expression associates with improved survival in lymph-node-positive rectal cancer.Nuclear ubiquitin C-terminal hydrolase L5 expression associates with increased patient survival in pancreatic ductal adenocarcinoma.The deubiquitinase UCHL5/UCH37 positively regulates Hedgehog signaling by deubiquitinating Smoothened.Structure and energetics of pairwise interactions between proteasome subunits RPN2, RPN13, and ubiquitin clarify a substrate recruitment mechanism.Dentin Dysplasia in Notum Knockout Mice.Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis.Expression and clinical significance of UCH37 in human esophageal squamous cell carcinoma.Control of Hedgehog Signalling by the Cilia-Regulated Proteasome.Covalent Rpn13-Binding Inhibitors for the Treatment of Ovarian Cancer
P2860
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P2860
Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development
description
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique PLoS ONE
@fr
artículu científicu espublizáu en 2010
@ast
im Oktober 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/10/27)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/10/27)
@nl
наукова стаття, опублікована в жовтні 2010
@uk
name
Regulators of the proteasome p ...... nct roles in mouse development
@ast
Regulators of the proteasome p ...... nct roles in mouse development
@en
Regulators of the proteasome p ...... nct roles in mouse development
@nl
type
label
Regulators of the proteasome p ...... nct roles in mouse development
@ast
Regulators of the proteasome p ...... nct roles in mouse development
@en
Regulators of the proteasome p ...... nct roles in mouse development
@nl
prefLabel
Regulators of the proteasome p ...... nct roles in mouse development
@ast
Regulators of the proteasome p ...... nct roles in mouse development
@en
Regulators of the proteasome p ...... nct roles in mouse development
@nl
P2093
P2860
P1433
P1476
Regulators of the proteasome p ...... nct roles in mouse development
@en
P2093
Amin Al-Shami
Brenda Gerhardt
Carrie Wilkins
Cynthia R. Shirley
David G. Potter
John J. Davis
Juliane Humphries
Kanchan G. Jhaver
Nianhua Xu
Robert Mullinax
P2860
P304
P356
10.1371/JOURNAL.PONE.0013654
P407
P50
P577
2010-10-27T00:00:00Z