Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease
about
Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington diseaseThe Joubert syndrome-associated missense mutation (V443D) in the Abelson-helper integration site 1 (AHI1) protein alters its localization and protein-protein interactionsThe ubiquitin proteasome system in glia and its role in neurodegenerative diseasesNeuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype.Huntingtin-associated protein 1 regulates exocytosis, vesicle docking, readily releasable pool size and fusion pore stability in mouse chromaffin cellsHuntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sortingHuntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and releasePrecursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processingLoss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiationHuntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in miceDietary intake in adults at risk for Huntington disease: analysis of PHAROS research participantsStudies on the Q175 Knock-in Model of Huntington's Disease Using Functional Imaging in Awake Mice: Evidence of Olfactory DysfunctionHuntingtin-associated protein 1: Eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestineProliferative hypothalamic neurospheres express NPY, AGRP, POMC, CART and Orexin-A and differentiate to functional neurons.HAP1 can sequester a subset of TBP in cytoplasmic inclusions via specific interaction with the conserved TBP(CORE).Huntingtin-associated protein-1 deficiency in orexin-producing neurons impairs neuronal process extension and leads to abnormal behavior in mice.RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model.Huntingtin-associated protein 1 interacts with breakpoint cluster region protein to regulate neuronal differentiation.Is Dysregulation of the HPA-Axis a Core Pathophysiology Mediating Co-Morbid Depression in Neurodegenerative Diseases?Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells.Postnatal loss of hap1 reduces hippocampal neurogenesis and causes adult depressive-like behavior in mice.Transcriptome-wide identification of preferentially expressed genes in the hypothalamus and pituitary glandHypothalamic overexpression of mutant huntingtin causes dysregulation of brown adipose tissue.Multiple pathways contribute to the pathogenesis of Huntington disease.Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice.Behavioral analysis of the huntingtin-associated protein 1 ortholog trak-1 in Caenorhabditis elegans.p150/glued modifies nuclear estrogen receptor functionAccumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.Huntingtin associated protein 1 and its functions.Impaired mitochondrial trafficking in Huntington's disease.Immunohistochemical localization of huntingtin-associated protein 1 in endocrine system of the rat.Polyglutamine toxicity in non-neuronal cells.Regulation of L-type Ca2+ Channel Activity and Insulin Secretion by Huntingtin-associated Protein 1.A C. elegans homolog of huntingtin-associated protein 1 is expressed in chemosensory neurons and in a number of other somatic cell types.DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome.Progress in developing transgenic monkey model for Huntington's disease.Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes.HAP1 Is Required for Endocytosis and Signalling of BDNF and Its Receptors in Neurons.The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival.Effect of Regulatory Network of Exosomes and microRNAs on Neurodegenerative Diseases
P2860
Q24292909-D6F218F8-6F3B-41B5-997A-E26F320C8A89Q24337384-81087620-E743-435B-A4CE-5D3E6C321EB7Q28391948-9EF7ED08-60C0-485C-B920-12D3C4C24A00Q28510053-FA349685-FF31-436A-A73E-A132249FB8B6Q28511792-CE943A0E-F1C6-48B8-84CB-1EE257F848C7Q28512400-8B96180B-7072-4113-AF81-AB472D9A527EQ28569078-744D9940-B161-46C7-8D3B-C65799DAE75AQ28573496-D48C0528-52CC-472D-9C16-C9CD95225756Q28582663-DAF56EC4-85E8-4B72-8750-412AA26A60FDQ28587677-A31AA472-45E2-49A3-8017-D7374CBCCD14Q30435217-82EA705F-FF19-492A-9DE1-52F7BA041A93Q30581974-EC570FB3-7B54-4DA9-9A49-2D843C85526AQ30822681-B813074F-56D4-415B-8D93-DDF824C03F07Q31011157-9AF6F1EF-6021-40D0-AC9B-A654E3CAF598Q33299019-631ECDCE-9537-464C-9068-647B5F95E007Q33855160-884708B9-627C-4408-A344-A86551B8090CQ33936969-8AE66BD6-2770-4012-9224-53BB855266D2Q35074377-E7B11EB2-3B27-4073-8C5B-A0B916704980Q35158376-5AA5B48F-302B-4633-9431-D131836E7FC8Q35350377-E9BD5B7F-794C-419E-BC41-D65F96E729EBQ35432034-181FD0ED-7C3A-477B-8051-0EBFF208A607Q35971350-F66851EA-3F7C-484C-91B4-50958358D644Q36106687-246A08ED-E468-4942-B5CF-40429C9CD1BBQ36686156-44A431AC-4877-46C0-8EDC-1E151F4D1000Q36701847-5CE8687A-5B40-4370-AEEF-DFF9837E1615Q37114262-F2FB640E-92D3-4BB4-B570-ED2B22E91303Q37176261-445C7103-C51C-43C1-A4D9-1C39D73EB468Q37323312-7B8D1BBB-4FB3-40FD-9747-6A87C72FBCF9Q37406748-928FF90F-5DC4-4014-B93F-AC8B6ED3498FQ37466100-400486DD-6F77-4BFC-B0E7-F4D8F4B29A44Q37643143-667C0C9A-3810-406E-9EE7-687B6ACB5D98Q37709833-86CB413C-71F4-483E-8CCD-1954C0C4444EQ38746454-736A2920-B4B0-414E-9183-F9BBF4D008EEQ41958028-D17B60D8-01EC-4B76-9AA0-282AAFE169FBQ42033560-CC5C0BDE-58B0-4DB5-86AD-BA44AF256783Q47974512-28874AEF-9C1D-4B16-AED3-F30F18D09C53Q48102811-79FEA8DC-6828-470A-982B-AA23B484745EQ48355553-F3752300-F05D-4E5A-9F5F-2BC4CEB22401Q55099888-B6DF0A80-5A3B-4859-B9EF-63023F2D1DA4Q58714289-4E3E8B0D-746A-47B7-92B3-007C074622F1
P2860
Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease
description
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Juli 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/07/30)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/07/30)
@nl
наукова стаття, опублікована в липні 2003
@uk
مقالة علمية (نشرت في 30-7-2003)
@ar
name
Lack of huntingtin-associated ...... ration in Huntington's disease
@ast
Lack of huntingtin-associated ...... ration in Huntington's disease
@en
Lack of huntingtin-associated ...... ration in Huntington's disease
@nl
type
label
Lack of huntingtin-associated ...... ration in Huntington's disease
@ast
Lack of huntingtin-associated ...... ration in Huntington's disease
@en
Lack of huntingtin-associated ...... ration in Huntington's disease
@nl
prefLabel
Lack of huntingtin-associated ...... ration in Huntington's disease
@ast
Lack of huntingtin-associated ...... ration in Huntington's disease
@en
Lack of huntingtin-associated ...... ration in Huntington's disease
@nl
P2093
P3181
P1476
Lack of huntingtin-associated ...... ration in Huntington's disease
@en
P2093
Chuxia Deng
Cui-Lin Li
Shi-Hua Li
Xiao-Jiang Li
Yong-Xing Zhou
Zhao-Xue Yu
P304
P3181
P356
10.1523/JNEUROSCI.23-17-06956.2003
P407
P577
2003-07-01T00:00:00Z