Role of phosphatidylinositol kinase in PDGF receptor signal transduction
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Src-family tyrosine kinases in activation of ERK-1 and p85/p110-phosphatidylinositol 3-kinase by G/CCKB receptorsGTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunitIdentification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gammaTyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transductionThe SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytesPhosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domainFunctions of the major tyrosine phosphorylation site of the PDGF receptor beta subunitIdentification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinasesThe 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase SypA tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligationIndependent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathwaysSpecific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activationIn vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinaseConstruction of an SH2 domain-binding site with mixed specificityThe isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphataseCharacterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid systemPhosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivoInteraction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changesExpression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression systemAssociation of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activityEps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signalsPhosphorylation of protein 4.1 on tyrosine-418 modulates its function in vitroInteractions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptorDirect association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 betaAutophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60srcPhosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinaseCloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85An Epstein-Barr virus transformation-associated membrane protein interacts with src family tyrosine kinasesSignal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequencesBrk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factorDirect association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinaseSchlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1Selective recognition of phosphatidylinositol 3,4,5-trisphosphate by a synthetic peptideTie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular systemGrowth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domainPlatelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell typesThe erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potencyDirect interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain.
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P2860
Role of phosphatidylinositol kinase in PDGF receptor signal transduction
description
1989 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի մարտին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Science
@fr
artículu científicu espublizáu en 1989
@ast
im März 1989 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1989/03/03)
@sk
vědecký článek publikovaný v roce 1989
@cs
wetenschappelijk artikel (gepubliceerd op 1989/03/03)
@nl
наукова стаття, опублікована в березні 1989
@uk
name
Role of phosphatidylinositol kinase in PDGF receptor signal transduction
@ast
Role of phosphatidylinositol kinase in PDGF receptor signal transduction
@en
Role of phosphatidylinositol kinase in PDGF receptor signal transduction
@nl
type
label
Role of phosphatidylinositol kinase in PDGF receptor signal transduction
@ast
Role of phosphatidylinositol kinase in PDGF receptor signal transduction
@en
Role of phosphatidylinositol kinase in PDGF receptor signal transduction
@nl
prefLabel
Role of phosphatidylinositol kinase in PDGF receptor signal transduction
@ast
Role of phosphatidylinositol kinase in PDGF receptor signal transduction
@en
Role of phosphatidylinositol kinase in PDGF receptor signal transduction
@nl
P2093
P356
P1433
P1476
Role of phosphatidylinositol kinase in PDGF receptor signal transduction
@en
P2093
J. A. Escobedo
L. T. Williams
S. R. Coughlin
P304
P356
10.1126/SCIENCE.2466336
P407
P577
1989-03-03T00:00:00Z