Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction
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Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cellsGTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunitIdentification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gammaTwo signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptorIn vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinaseGrb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptorsPhosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivoInteraction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changesCloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85Receptor tyrosine kinase signaling: regulating neural crest development one phosphate at a timePI3K-mediated PDGFRα signaling regulates survival and proliferation in skeletal development through p53-dependent intracellular pathwaysMutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblastsA role for Src in signal relay by the platelet-derived growth factor alpha receptorEAST, an epidermal growth factor receptor- and Eps15-associated protein with Src homology 3 and tyrosine-based activation motif domains.The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor.Ciliary transport regulates PDGF-AA/αα signaling via elevated mammalian target of rapamycin signaling and diminished PP2A activity.The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors.Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling.Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members.An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway.Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectivelyeps15, a novel tyrosine kinase substrate, exhibits transforming activity.SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptorsNovel oncogenic PDGFRA mutations in pediatric high-grade gliomas.PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRαThe assembly of signalling complexes by receptor tyrosine kinases.Identification of the receptor-associated signaling enzymes that are required for platelet-derived growth factor-AA-dependent chemotaxis and DNA synthesis.Phosphatidylinositol-3' kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase.Platelet-derived growth factor alpha and beta receptors have overlapping functional activities towards fibroblasts.PDGF alpha- and beta-receptors activate unique and common signal transduction pathways.Involvement of a phosphotyrosine protein phosphatase in the suppression of platelet-derived growth factor receptor autophosphorylation in ras-transformed cells.Simultaneous induction of stimulatory and inhibitory signals by PDGF.Receptor regulation of phosphoinositide 3-hydroxykinase in the NG115-401L-C3 neuronal cell line: stimulation by insulin-like growth factor-I.Mitogenic signal transduction in normal and transformed 32D hematopoietic cells.Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phosphopeptide affinity columns.Herpes simplex virus requires VP11/12 to activate Src family kinase-phosphoinositide 3-kinase-Akt signaling.Regulation of phosphatidylinositol 3'-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit.The oncogenic FIP1L1-PDGFRα fusion protein displays skewed signaling properties compared to its wild-type PDGFRα counterpart.Lycopene binding compromised PDGF-AA/-AB signaling and migration in smooth muscle cells and fibroblasts: prediction of the possible lycopene binding site within PDGF.
P2860
Q24292157-4E6147D8-2BC6-44C8-89F7-336A8CBC6B52Q24292767-E569C3C2-ACB7-433F-80E0-3FB71A50BE07Q24293518-A8E6B891-7522-48A9-9A43-8F963833EC22Q24311075-6EFECF0F-B437-4033-A737-2996D8670410Q24314627-B4AF40E7-802C-4580-9F3C-B43E3F67072AQ24322730-16A23000-6AF9-4451-A070-F49B7088535AQ24336223-AFD475CC-FD08-4802-A588-AF5BEDAB8105Q24337412-D4568A78-4153-4EF8-8E75-F7AFEFE13F83Q24629213-41A9D174-E909-4336-9E8F-6AB7BF64BDF2Q28083779-FD33E532-084D-4BAA-A7A4-290344DE75DDQ28512064-37766C61-6B9B-47AA-B363-DDCB24305DA2Q28587864-1E6B48EA-6969-4306-B067-465E8364ED47Q28645730-38B6434C-2D9B-40CF-8956-CCC1E1C52F54Q30176098-CA6EA94C-A761-463F-8464-E9C1636E540BQ30195438-586071FE-67E3-4A9A-8644-21663AF30B6CQ34960781-70EBB6CB-FBA3-402E-B98C-DD3A9BA92784Q35769059-60344A56-5E74-4F2E-9783-C2B415CEBE3CQ36234748-AA06DD50-BCE4-459D-86C3-27C936B12A77Q36564274-BCC6E00B-795D-4427-A357-F0670CC285C9Q36643816-8A0672B8-C315-4F2F-879F-AF59E317AE5BQ36644261-D7C434C7-AB02-4A5F-BCFC-3B9DC7F020DEQ36658598-FEC09C87-6CAF-4C1C-A975-EB3CB400B6C4Q36701817-D3FD1C9A-0203-4F53-8583-9C215DD5A3C9Q36962473-F8FC929C-E640-4A40-ADD5-0D95F7B7CAC4Q37238690-D79F7D60-B2D2-4AF9-A42F-447A1A6B7F4AQ37461467-586D62E9-6B32-4D24-807C-889468D384CDQ40853794-2C8344A7-E382-49F4-9ACA-41CD0BE99AFDQ40927232-4FD64B26-FB56-46A9-9D72-B638403CAE33Q41174456-7CC00026-5CC7-43E0-98B5-501C20CCD096Q41175151-B58717D3-EB50-481A-BB79-6686BCC8346DQ41516226-3CAB943D-8C77-48FA-8887-015B7BD7A084Q41544830-EAA0639B-135F-449F-9F82-0DC1B54B8AA1Q41553992-11F710A5-55A6-4CC8-849C-D90EBB7E0A29Q41565921-B3C3C5C6-9010-466C-98D3-3C6C6FFF8C97Q41660466-9B626DE2-FA69-4D16-9800-18177E207ABBQ41787609-C5B569AC-5262-4017-8E1B-031709439E0DQ41949488-86097033-362E-4EB2-A6FB-437E437116BDQ42066856-A77DAFE6-25DD-4A8C-A951-278E96A44404Q42586449-E97C0EFB-071A-4C1C-886F-B3A7BB55EF6FQ43125682-0B861195-30F9-4D6C-890B-67F71491EB70
P2860
Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction
description
1991 nî lūn-bûn
@nan
1991 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Tyrosine mutations within the ...... hemotactic signal transduction
@ast
Tyrosine mutations within the ...... hemotactic signal transduction
@en
Tyrosine mutations within the ...... hemotactic signal transduction
@nl
type
label
Tyrosine mutations within the ...... hemotactic signal transduction
@ast
Tyrosine mutations within the ...... hemotactic signal transduction
@en
Tyrosine mutations within the ...... hemotactic signal transduction
@nl
prefLabel
Tyrosine mutations within the ...... hemotactic signal transduction
@ast
Tyrosine mutations within the ...... hemotactic signal transduction
@en
Tyrosine mutations within the ...... hemotactic signal transduction
@nl
P2093
P2860
P921
P356
P1476
Tyrosine mutations within the ...... hemotactic signal transduction
@en
P2093
D Lombardi
J H Pierce
J S Gutkind
M A Heidaran
M Ruggiero
S A Aaronson
P2860
P304
P356
10.1128/MCB.11.7.3780
P407
P577
1991-07-01T00:00:00Z