The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
about
Functional differences in visceral and subcutaneous fat pads originate from differences in the adipose stem cellEpigenetic regulation of caloric restriction in agingMicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1Polycomb group genes: keeping stem cell activity in balancehuASH1 protein, a putative transcription factor encoded by a human homologue of the Drosophila ash1 gene, localizes to both nuclei and cell-cell tight junctionsTBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescencePhysical and functional interaction between PML and TBX2 in the establishment of cellular senescenceBypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locusMyeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanismsUBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activityLoss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1α mediated by the PTEN/PI3K/Akt pathwayN-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNAIdentification of a polymorphism in the RING finger of human Bmi-1 that causes its degradation by the ubiquitin-proteasome systemRecognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complexPTEN inhibits BMI1 function independently of its phosphatase activityMAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cellsSeveral distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locusRegulation of ploidy and senescence by the AMPK-related kinase NUAK1Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressorAlternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback controlStable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligaseBmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways.The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cellsSet domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibitionGrowth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASGEpigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in healthBmi1, stem cells, and senescence regulationThe E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complexLong non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor geneBMI1-mediated histone ubiquitylation promotes DNA double-strand break repairThe matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healingBMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repairPolycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistanceBMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repressionBmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferationThe polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity
P2860
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P2860
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
description
1999 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 1999
@ast
scientific article (publication date: 14 January 1999)
@en
wetenschappelijk artikel (gepubliceerd op 1999/01/14)
@nl
наукова стаття, опублікована в січні 1999
@uk
مقالة علمية (نشرت في 14-1-1999)
@ar
name
The oncogene and Polycomb-grou ...... scence through the ink4a locus
@ast
The oncogene and Polycomb-grou ...... scence through the ink4a locus
@en
type
label
The oncogene and Polycomb-grou ...... scence through the ink4a locus
@ast
The oncogene and Polycomb-grou ...... scence through the ink4a locus
@en
prefLabel
The oncogene and Polycomb-grou ...... scence through the ink4a locus
@ast
The oncogene and Polycomb-grou ...... scence through the ink4a locus
@en
P2093
P3181
P356
P1433
P1476
The oncogene and Polycomb-grou ...... scence through the ink4a locus
@en
P2093
DePinho RA
van Lohuizen M
P2888
P3181
P356
10.1038/16476
P407
P577
1999-01-14T00:00:00Z
P5875
P6179
1033156851