A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.
about
hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathwaysPleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteinsPhosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivoGrap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathwayAsh/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGFBcr-Abl oncoproteins bind directly to activators of the Ras signalling pathwayRREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomasThe human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.Ahi-1, a novel gene encoding a modular protein with WD40-repeat and SH3 domains, is targeted by the Ahi-1 and Mis-2 provirus integrationsTight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domainsProtein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to RasIdentification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimerac-Abl kinase regulates the protein binding activity of c-CrkDual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptorTyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activationShc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cellsCRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cellsIdentification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domainsGRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulationPhosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinaseBinding of NCK to SOS and activation of ras-dependent gene expressionDissecting Nck/Dock signaling pathways in Drosophila visual system.The transmembranal and cytoplasmic forms of protein tyrosine phosphatase epsilon physically associate with the adaptor molecule Grb2Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growthAutoimmunity in stiff-Man syndrome with breast cancer is targeted to the C-terminal region of human amphiphysin, a protein similar to the yeast proteins, Rvs167 and Rvs161The SH2 domain-containing proteins in 21 species establish the provenance and scope of phosphotyrosine signaling in eukaryotesAssociation of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cellsGrb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interactionSLP76 and SLP65: complex regulation of signalling in lymphocytes and beyondIdentification of a novel 135-kDa Grb2-binding protein in osteoclastsShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation.p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domainsThe role of the PH domain in the signal-dependent membrane targeting of Sos.Splicing isoforms of rat Ash/Grb2. Isolation and characterization of the cDNA and genomic DNA clones and implications for the physiological roles of the isoformsCrkII signals from epidermal growth factor receptor to RasMutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblastsMolecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptorsThe proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cellsDominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu
P2860
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P248
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P2860
A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.
description
1993 nî lūn-bûn
@nan
1993 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
A Drosophila SH2-SH3 adaptor p ...... nine nucleotide exchange, Sos.
@ast
A Drosophila SH2-SH3 adaptor p ...... nine nucleotide exchange, Sos.
@en
type
label
A Drosophila SH2-SH3 adaptor p ...... nine nucleotide exchange, Sos.
@ast
A Drosophila SH2-SH3 adaptor p ...... nine nucleotide exchange, Sos.
@en
prefLabel
A Drosophila SH2-SH3 adaptor p ...... nine nucleotide exchange, Sos.
@ast
A Drosophila SH2-SH3 adaptor p ...... nine nucleotide exchange, Sos.
@en
P2093
P1433
P1476
A Drosophila SH2-SH3 adaptor p ...... nine nucleotide exchange, Sos.
@en
P2093
Henkemeyer M
Margolis B
Olivier JP
Schlessinger J
P304
P356
10.1016/0092-8674(93)90170-U
P407
P577
1993-04-01T00:00:00Z