Characterization of the hemin-sensitive eukaryotic initiation factor 2alpha kinase from mouse nonerythroid cells.
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Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinaseAssociation of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activationPhosphorylation of initiation factor eIF2 in response to stress conditions is mediated by acidic ribosomal P1/P2 proteins in Saccharomyces cerevisiae.IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L proteinSalicylates trigger protein synthesis inhibition in a protein kinase R-like endoplasmic reticulum kinase-dependent mannerHeme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiencyMechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signallingAntiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA virusesPharmacological modulation of the retinal unfolded protein response in Bardet-Biedl syndrome reduces apoptosis and preserves light detection abilityAutophosphorylation of heme-regulated eukaryotic initiation factor 2α kinase and the role of the modification in catalysisHeme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemiaTIA-1 is a translational silencer that selectively regulates the expression of TNF-alphaRNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granulesEvidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granulesDynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granulesInhibition of protein synthesis in cortical neurons during exposure to hydrogen peroxide.Sensory denervation modulates eIF-2 alpha kinase expression in the rabbit lacrimal glandHepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress toneDual role for Hsc70 in the biogenesis and regulation of the heme-regulated kinase of the alpha subunit of eukaryotic translation initiation factor 2Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses.GCN2 has inhibitory effect on human immunodeficiency virus-1 protein synthesis and is cleaved upon viral infectionCytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal.The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation.Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias.Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake.An mRNA-specific tRNAi carrier eIF2A plays a pivotal role in cell proliferation under stress conditions: stress-resistant translation of c-Src mRNA is mediated by eIF2A.Endoplasmic reticulum proteostasis in hepatic steatosis.The integrated stress response.PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.Phosphorylation of eIF2alpha in response to 26S proteasome inhibition is mediated by the haem-regulated inhibitor (HRI) kinase.The chemotherapeutic agent bortezomib induces the formation of stress granules.Role of mitogen-activated protein kinase Sty1 in regulation of eukaryotic initiation factor 2alpha kinases in response to environmental stress in Schizosaccharomyces pombe.15-deoxyspergualin inhibits eukaryotic protein synthesis through eIF2alpha phosphorylation.The heme-regulated eukaryotic initiation factor 2alpha kinase. A potential regulatory target for control of protein synthesis by diffusible gases.Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2.Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress.Functional characterization of Drosophila melanogaster PERK eukaryotic initiation factor 2alpha (eIF2alpha) kinase.The eIF2α kinase Heme Regulated Inhibitor (HRI) protects the host from infection by regulating intracellular pathogen trafficking.The eIF2-alpha kinase HRI: a potential target beyond the red blood cell.SMN deficiency reduces cellular ability to form stress granules, sensitizing cells to stress.
P2860
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P2860
Characterization of the hemin-sensitive eukaryotic initiation factor 2alpha kinase from mouse nonerythroid cells.
description
1998 nî lūn-bûn
@nan
1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Characterization of the hemin- ...... from mouse nonerythroid cells.
@ast
Characterization of the hemin- ...... from mouse nonerythroid cells.
@en
type
label
Characterization of the hemin- ...... from mouse nonerythroid cells.
@ast
Characterization of the hemin- ...... from mouse nonerythroid cells.
@en
prefLabel
Characterization of the hemin- ...... from mouse nonerythroid cells.
@ast
Characterization of the hemin- ...... from mouse nonerythroid cells.
@en
P2093
P2860
P356
P1476
Characterization of the hemin- ...... from mouse nonerythroid cells.
@en
P2093
P2860
P304
32340-32346
P356
10.1074/JBC.273.48.32340
P407
P577
1998-11-01T00:00:00Z