Improved nuclear localization of DNA-binding polyamides.
about
Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamideAllosteric modulation of DNA by small moleculesStructural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor BindingInhibiting gene expression with locked nucleic acids (LNAs) that target chromosomal DNA.Next generation hairpin polyamides with (R)-3,4-diaminobutyric acid turn unit.Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cellsRational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3.Modifications at the C-terminus to improve pyrrole-imidazole polyamide activity in cell culture.Investigation of the relative cellular permeability of DNA-binding pyrrole-imidazole polyamides.Binding studies of a large antiviral polyamide to a natural HPV sequence.HPV episome levels are potently decreased by pyrrole-imidazole polyamides.A C-14 labeled Py-Im polyamide localizes to a subcutaneous prostate cancer tumor.DNA-binding small molecules as inhibitors of transcription factors.Progress and prospects of pyrrole-imidazole polyamide-fluorophore conjugates as sequence-selective DNA probes.Noncanonical mechanisms to regulate nuclear receptor signaling.Controlling gene networks and cell fate with precision-targeted DNA-binding proteins and small-molecule-based genome readers.Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.Quantitative microarray profiling of DNA-binding moleculesFluorescent probes for nucleic Acid visualization in fixed and live cells.Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove bindersEnhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns.Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide.Characterization and solubilization of pyrrole-imidazole polyamide aggregatesAlpha-diaminobutyric acid-linked hairpin polyamides.Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice.Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide.Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia.Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dicationTargeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide.Activity of a Py-Im polyamide targeted to the estrogen response element.In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography.Cyclic pyrrole-imidazole polyamides targeted to the androgen response element.Solution-phase synthesis of pyrrole-imidazole polyamidesAnimal toxicity of hairpin pyrrole-imidazole polyamides varies with the turn unit.Sequence specific and high affinity recognition of 5'-ACGCGT-3' by rationally designed pyrrole-imidazole H-pin polyamides: thermodynamic and structural studiesOligomerization route to Py-Im polyamide macrocycles.Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expressionSmall-molecule regulators that mimic transcription factorsApproaches to target the genome and its epigenome in cancer.Development of a molecule-recognized promoter DNA sequence for inhibition of HER2 expression.
P2860
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P2860
Improved nuclear localization of DNA-binding polyamides.
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Improved nuclear localization of DNA-binding polyamides.
@ast
Improved nuclear localization of DNA-binding polyamides.
@en
type
label
Improved nuclear localization of DNA-binding polyamides.
@ast
Improved nuclear localization of DNA-binding polyamides.
@en
prefLabel
Improved nuclear localization of DNA-binding polyamides.
@ast
Improved nuclear localization of DNA-binding polyamides.
@en
P2093
P2860
P356
P1476
Improved nuclear localization of DNA-binding polyamides.
@en
P2093
Claire S Jacobs
Michelle E Farkas
Nicholas G Nickols
P2860
P304
P356
10.1093/NAR/GKL1042
P407
P50
P577
2006-12-14T00:00:00Z