Proteasomal degradation of TRIM5alpha during retrovirus restriction
about
TRIM5α associates with proteasomal subunits in cells while in complex with HIV-1 virionsp62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha.TRIM family proteins and their emerging roles in innate immunityEvolution of foamy viruses: the most ancient of all retrovirusesConformational Adaptation of Asian Macaque TRIMCyp Directs Lineage Specific Antiviral ActivityRhesus TRIM5α disrupts the HIV-1 capsid at the inter-hexamer interfacesLv4 Is a Capsid-Specific Antiviral Activity in Human Blood Cells That Restricts Viruses of the SIVMAC/SIVSM/HIV-2 Lineage Prior to IntegrationPrimate TRIM5 proteins form hexagonal nets on HIV-1 capsids.Recruitment and dynamics of proteasome association with rhTRIM5α cytoplasmic complexes during HIV-1 infection.Functional evidence for the involvement of microtubules and dynein motor complexes in TRIM5α-mediated restriction of retroviruses.Novel approaches to inhibiting HIV-1 replication.FIV Gag: virus assembly and host-cell interactions.Determinants for the rhesus monkey TRIM5alpha-mediated block of the late phase of HIV-1 replication.The specificity of TRIM5 alpha-mediated restriction is influenced by its coiled-coil domain.Origin and evolution of TRIM proteins: new insights from the complete TRIM repertoire of zebrafish and pufferfishA single amino acid of human immunodeficiency virus type 2 capsid protein affects conformation of two external loops and viral sensitivity to TRIM5α.TRIM5alpha disrupts the structure of assembled HIV-1 capsid complexes in vitro.Cyclophilin A restricts influenza A virus replication through degradation of the M1 protein.Cytoplasmic body component TRIM5{alpha} requires lipid-enriched microdomains for efficient HIV-1 restriction.Hare TRIM5α restricts divergent retroviruses and exhibits significant sequence variation from closely related lagomorpha TRIM5 genesDelaying reverse transcription does not increase sensitivity of HIV-1 to human TRIM5α.Insights into cellular factors that regulate HIV-1 replication in human cellsA novel aminoacid determinant of HIV-1 restriction in the TRIM5α variable 1 region isolated in a random mutagenic screenRole of TRIM5α RING domain E3 ubiquitin ligase activity in capsid disassembly, reverse transcription blockade, and restriction of simian immunodeficiency virus.Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins.Contribution of E3-ubiquitin ligase activity to HIV-1 restriction by TRIM5alpha(rh): structure of the RING domain of TRIM5alpha.TRIM5α does not affect simian immunodeficiency virus SIV(mac251) replication in vaccinated or unvaccinated Indian rhesus macaques following intrarectal challenge exposureRING domain mutations uncouple TRIM5α restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoatingTRIM5 structure, HIV-1 capsid recognition, and innate immune signalingRING Dimerization Links Higher-Order Assembly of TRIM5α to Synthesis of K63-Linked Polyubiquitin.TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.Advances in cell and gene-based therapies for cystic fibrosis lung diseaseTRIM5 and the Regulation of HIV-1 Infectivity.Ovine TRIM5α can restrict visna/maedi virus.Preclinical Assessment of Mutant Human TRIM5α as an Anti-HIV-1 TransgeneUnderstanding restriction factors and intrinsic immunity: insights and lessons from the primate lentiviruses.Host restriction factors in retroviral infection: promises in virus-host interaction.The interdomain linker region of HIV-1 capsid protein is a critical determinant of proper core assembly and stability.TRIM5α Degradation via Autophagy Is Not Required for Retroviral Restriction.Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication.
P2860
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P2860
Proteasomal degradation of TRIM5alpha during retrovirus restriction
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Proteasomal degradation of TRIM5alpha during retrovirus restriction
@ast
Proteasomal degradation of TRIM5alpha during retrovirus restriction
@en
Proteasomal degradation of TRIM5alpha during retrovirus restriction.
@nl
type
label
Proteasomal degradation of TRIM5alpha during retrovirus restriction
@ast
Proteasomal degradation of TRIM5alpha during retrovirus restriction
@en
Proteasomal degradation of TRIM5alpha during retrovirus restriction.
@nl
prefLabel
Proteasomal degradation of TRIM5alpha during retrovirus restriction
@ast
Proteasomal degradation of TRIM5alpha during retrovirus restriction
@en
Proteasomal degradation of TRIM5alpha during retrovirus restriction.
@nl
P2860
P1433
P1476
Proteasomal degradation of TRIM5alpha during retrovirus restriction
@en
P2093
Christopher Aiken
Christopher James Rold
P2860
P304
P356
10.1371/JOURNAL.PPAT.1000074
P577
2008-05-23T00:00:00Z