Synthetic mRNA splicing modulator compounds with in vivo antitumor activity. - sprookjes - yvandenbroek - TriplyDB

Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.

Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.

http://www.wikidata.org/entity/Q33570837

about

Modulating splicing with small molecular inhibitors of the spliceosome The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia.Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.Translating Nature's Library: The Bryostatins and Function-Oriented Synthesis A high-throughput assay to identify small-molecule modulators of alternative pre-mRNA splicing.Radiosynthesis of antitumor spliceosome modulators.Design, synthesis and initial biological evaluation of a novel pladienolide analog scaffold.Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1 Ruthenium-Catalyzed Olefin Metathesis after Tetra-n-butylammonium Fluoride-Mediated Desilylation.Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464.Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs.Multiple components of the spliceosome regulate Mcl1 activity in neuroblastoma.Molecular pathogenesis of myelodysplastic syndromes.Emerging roles of the spliceosomal machinery in myelodysplastic syndromes and other hematological disorders.The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy.Design and synthesis of analogues of natural products.Pre-mRNA splicing-modulatory pharmacophores: the total synthesis of herboxidiene, a pladienolide-herboxidiene hybrid analog and related derivatives.Sudemycin E influences alternative splicing and changes chromatin modifications.Splicing factor gene mutations in hematologic malignancies.Effects of thailanstatins on glucocorticoid response in trabecular meshwork and steroid-induced glaucoma Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing.Optimization of antitumor modulators of pre-mRNA splicing.Expression levels of SF3B3 correlate with prognosis and endocrine resistance in estrogen receptor-positive breast cancer.A Challenging Pie to Splice: Drugging the Spliceosome.Alternative Splicing as a Target for Cancer Treatment.A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore.

P2860

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P2860

Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.

http://www.wikidata.org/entity/Q33570837

description

2009 nî lūn-bûn

@nan

2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.

@ast

Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.

@en

Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.

@nl

type

label

Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.

@ast

Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.

@en

Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.

@nl

prefLabel

Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.

@ast

Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.

@en

Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.

@nl

P1433

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P1433

Journal of Medicinal Chemistry

P1476

Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.

@en

P2093

Alan Pourpak

http://www.w3.org/2001/XMLSchema#string

Chandraiah Lagisetti

http://www.w3.org/2001/XMLSchema#string

Jill M Lahti

http://www.w3.org/2001/XMLSchema#string

Judith Hyle

http://www.w3.org/2001/XMLSchema#string

Qin Jiang

http://www.w3.org/2001/XMLSchema#string

Stephan W Morris

http://www.w3.org/2001/XMLSchema#string

Thomas R Webb

http://www.w3.org/2001/XMLSchema#string

Tinopiwa Goronga

http://www.w3.org/2001/XMLSchema#string

Xiaoli Cui

http://www.w3.org/2001/XMLSchema#string

P2860

Quantitative structure-activity relationship of human neutrophil collagenase (MMP-8) inhibitors using comparative molecular field analysis and X-ray structure analysis

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

Stereoselective synthesis and anti-inflammatory activities of 6- and 7-membered dioxacycloalkanes

MLL translocations, histone modifications and leukaemia stem-cell development

The structure and function of proteins involved in mammalian pre-mRNA splicing

A fragment library based on Gaussian mixtures predicting favorable molecular interactions.

Solution-phase parallel synthesis of carbamates as gamma-secretase inhibitors.

An efficient, inexpensive, and shelf-stable diazotransfer reagent: imidazole-1-sulfonyl azide hydrochloride.

Physicochemical aspects of the enzymatic hydrolysis of carboxylic esters.

Design of ester prodrugs to enhance oral absorption of poorly permeable compounds: challenges to the discovery scientist.

P304

6979-6990

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scholarly article

P356

10.1021/JM901215M

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P407

P433

22

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P478

52

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2009-11-01T00:00:00Z

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P5875

38056022

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P698

19877647

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P932

2801547

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