Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance - sprookjes - yvandenbroek - TriplyDB

Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance

Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance

http://www.wikidata.org/entity/Q33656136

about

Second messenger role for Mg2+ revealed by human T-cell immunodeficiency T cell receptor signalling in the control of regulatory T cell differentiation and function Disrupted regulatory T cell homeostasis in inflammatory bowel diseases Cellular and molecular determinants for the development of natural and induced regulatory T cells Phospholipase Cγ2 (PLCγ2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses Phosphorylation site dynamics of early T-cell receptor signaling LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection In silico transcriptional regulation and functional analysis of dengue shock syndrome associated SNPs in PLCE1 and MICB genes Analysis of sirtuin 1 expression reveals a molecular explanation of IL-2-mediated reversal of T-cell tolerance Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation.Impairment of kindling development in phospholipase Cγ1 heterozygous mice.The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation.A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease.Lipid signaling in T-cell development and function In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness.Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells Regulatory T cells require TCR signaling for their suppressive function Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1 T cell receptor signaling that regulates the development of intrathymic natural regulatory T cells.STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function.Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance CD5-CK2 Signaling Modulates Erk Activation and Thymocyte Survival.Phospholipase Cγ2 plays a role in TCR signal transduction and T cell selection.A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry.Role of diacylglycerol kinases in T cell development and function.Regulation of Lipid Signaling by Diacylglycerol Kinases during T Cell Development and Function Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1 ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival.Activated PLC-γ1 is catalytically induced at LAT but activated PLC-γ1 is localized at both LAT- and TCR-containing complexes.Immunodeficiency due to defects in store-operated calcium entry.Physiological and pathophysiological functions of SOCE in the immune system.The critical role of STIM1-dependent Ca2+ signalling during T-cell development and activation.Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells.Lipid and Protein Co-Regulation of PI3K Effectors Akt and Itk in Lymphocytes.Receptor signaling in immune cell development and function.A PLC-γ1 Feedback Pathway Regulates Lck Substrate Phosphorylation at the T-Cell Receptor and SLP-76 Complex.Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.Diacylglycerol metabolism attenuates T-cell receptor signaling and alters thymocyte differentiation.Lypopolysaccharide downregulates the expression of selected phospholipase C genes in cultured endothelial cells.

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P2860

Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance

http://www.wikidata.org/entity/Q33656136

description

2010 nî lūn-bûn

@nan

2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance

@ast

Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance

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type

label

Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance

@ast

Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance

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prefLabel

Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance

@ast

Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance

@en

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Journal of Experimental Medicine

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Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance

@en

P2093

Andy Podd

http://www.w3.org/2001/XMLSchema#string

Calvin B Williams

http://www.w3.org/2001/XMLSchema#string

Demin Wang

http://www.w3.org/2001/XMLSchema#string

Dipica Haribhai

http://www.w3.org/2001/XMLSchema#string

Guoping Fu

http://www.w3.org/2001/XMLSchema#string

Jack Gorski

http://www.w3.org/2001/XMLSchema#string

James Schuman

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Lie Di

http://www.w3.org/2001/XMLSchema#string

Maryam Yassai

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Mei Yu

http://www.w3.org/2001/XMLSchema#string

P2860

RasGRP links T-cell receptor signaling to Ras

FOXP3 controls regulatory T cell function through cooperation with NFAT

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

Control of regulatory T cell development by the transcription factor Foxp3

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Transcription factors of the NFAT family: regulation and function

Regulation of phosphoinositide-specific phospholipase C

An essential role for Scurfin in CD4+CD25+ T regulatory cells

Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins.

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309-318

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10.1084/JEM.20090880

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2

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207

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2010-02-01T00:00:00Z

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41399087

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20123962

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2822604

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