Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis
about
Amyloid-β and Astrocytes Interplay in Amyloid-β Related DisordersElusive roles for reactive astrocytes in neurodegenerative diseasesAccumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neuronsDeletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficitsTFEB at a glanceAutophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice.Regulation of the transcription factor EB-PGC1α axis by beclin-1 controls mitochondrial quality and cardiomyocyte death under stressmTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseasesHippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathologyNeuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis.Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway.Expression of familial Alzheimer disease presenilin 1 gene attenuates vesicle traffic and reduces peptide secretion in cultured astrocytes devoid of pathologic tissue environment.Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency.Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway.Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease.TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits.Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microgliaThe Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB PerspectiveThe lysosome as a command-and-control center for cellular metabolism.New advances on glial activation in health and disease.Induced Pluripotent Stem Cells Derived from Alzheimer's Disease Patients: The Promise, the Hope and the Path Ahead.Iron and Neurodegeneration: Is Ferritinophagy the Link?Astrocytes: a central element in neurological diseases.Study of Exosomes Shed New Light on Physiology of Amyloidogenesis.Mechanisms of cellular plasticity in cerebral perivascular region.Transcription factor EB: from master coordinator of lysosomal pathways to candidate therapeutic target in degenerative storage diseases.Astrocyte dysfunction in Alzheimer disease.Autophagy modulation: a potential therapeutic approach in cardiac hypertrophy.The spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases.Transcription Factor EB Is Selectively Reduced in the Nuclear Fractions of Alzheimer's and Amyotrophic Lateral Sclerosis Brains.Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer's-Disease Related Pathology.Iowa Mutant Apolipoprotein A-I (ApoA-IIowa) Fibrils Target Lysosomes.Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition.A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition.Altered Cholesterol Intracellular Trafficking and the Development of Pathological Hallmarks of Sporadic AD.GULP1/CED-6 ameliorates amyloid-β toxicity in a Drosophila model of Alzheimer's disease.Impaired Protein Quality Control During Left Ventricular Remodeling in Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor.Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease.TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux.Diversity of astroglial responses across human neurodegenerative disorders and brain aging.
P2860
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P2860
Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis
description
2014 nî lūn-bûn
@nan
2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Enhancing astrocytic lysosome ...... es amyloid plaque pathogenesis
@ast
Enhancing astrocytic lysosome ...... es amyloid plaque pathogenesis
@en
type
label
Enhancing astrocytic lysosome ...... es amyloid plaque pathogenesis
@ast
Enhancing astrocytic lysosome ...... es amyloid plaque pathogenesis
@en
prefLabel
Enhancing astrocytic lysosome ...... es amyloid plaque pathogenesis
@ast
Enhancing astrocytic lysosome ...... es amyloid plaque pathogenesis
@en
P2093
P2860
P1476
Enhancing astrocytic lysosome ...... es amyloid plaque pathogenesis
@en
P2093
Abhinav Diwan
Dorothy R Schuler
Ernesto Gonzales
Haiyan Liu
Jack M Burchett
John R Cirrito
Qingli Xiao
Ronaldo Perez
P2860
P304
P356
10.1523/JNEUROSCI.3788-13.2014
P407
P50
P577
2014-07-01T00:00:00Z