Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination - sprookjes - yvandenbroek - TriplyDB

Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination

Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination

http://www.wikidata.org/entity/Q33950143

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Internal IgH class switch region deletions are position-independent and enhanced by AID expression Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis.AID and mismatch repair in antibody diversification.De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination.AID to overcome the limitations of genomic information by introducing somatic DNA alterations.Accessibility control and machinery of immunoglobulin class switch recombination.Class-switch recombination: after the dawn of AID.Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination.The role of the non-homologous end-joining pathway in lymphocyte development.Hyper-immunoglobulin M syndromes caused by intrinsic B-lymphocyte defects.H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation DNA-dependent protein kinase activity is not required for immunoglobulin class switching.Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions Mapping of a functional recombination motif that defines isotype specificity for mu-->gamma3 switch recombination implicates NF-kappaB p50 as the isotype-specific switching factor Codon insertion and deletion functions as a somatic diversification mechanism in human antibody repertoires.Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability.NHEJ-deficient DT40 cells have increased levels of immunoglobulin gene conversion: evidence for a double strand break intermediate.AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID.AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner.Gene Conversion-Like Events in the Diversification of Human Rearranged IGHV3-23*01 Gene Sequences.AID mutant analyses indicate requirement for class-switch-specific cofactors.Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation.Pneumococcal conjugate vaccine followed by pneumococcal polysaccharide vaccine; immunogenicity in patients with ataxia-telangiectasia.Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination.Genomic rearrangements in the CFTR gene: extensive allelic heterogeneity and diverse mutational mechanisms.Genomic characterization of the chromosomal breakpoints of t(4;14) of multiple myeloma suggests more than one possible aetiological mechanism.Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination.Meta-Analysis of gross insertions causing human genetic disease: Novel mutational mechanisms and the role of replication slippage

P2860

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P2860

Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination

http://www.wikidata.org/entity/Q33950143

description

2001 nî lūn-bûn

@nan

2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2001年の論文

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2001年論文

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2001年論文

@zh-hant

2001年論文

@zh-hk

2001年論文

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2001年論文

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2001年论文

@wuu

name

Variable deletion and duplicat ...... in class-switch recombination

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Variable deletion and duplicat ...... in class-switch recombination

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Variable deletion and duplicat ...... in class-switch recombination

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Variable deletion and duplicat ...... in class-switch recombination

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Variable deletion and duplicat ...... in class-switch recombination

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Variable deletion and duplicat ...... in class-switch recombination

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P1433

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Variable deletion and duplicat ...... in class-switch recombination

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P2093

Chen X

http://www.w3.org/2001/XMLSchema#string

Honjo T

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Kinoshita K

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P2860

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes

Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease

Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process

Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

Analysis of the open region of RNA polymerase II transcription complexes in the early phase of elongation

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

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13860-13865

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10.1073/PNAS.241524898

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24

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98

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11717442

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