Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. - sprookjes - yvandenbroek - TriplyDB

Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.

Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.

http://www.wikidata.org/entity/Q33985882

about

The dynamic cilium in human diseases Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals Experimental therapies and ongoing clinical trials to slow down progression of ADPKD The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologies The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation PPAR-gamma agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease Loss of oriented cell division does not initiate cyst formation RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models.Advances in the pathogenesis and treatment of polycystic kidney disease Molecular advances in autosomal dominant polycystic kidney disease.Abnormalities in focal adhesion complex formation, regulation, and function in human autosomal recessive polycystic kidney disease epithelial cells Novel targets for the treatment of autosomal dominant polycystic kidney disease.Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease.Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease Intratubular hydrodynamic forces influence tubulointerstitial fibrosis in the kidney.Kidney-specific inactivation of Ofd1 leads to renal cystic disease associated with upregulation of the mTOR pathway The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation.Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD Rosiglitazone inhibits transforming growth factor-β1 mediated fibrogenesis in ADPKD cyst-lining epithelial cells.Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease.ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice.Mechanotransduction in the renal tubule HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells.Exploring the genetic basis of early-onset chronic kidney disease.Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis.Cyclic AMP-mediated cyst expansion Ectopic expression of Cux1 is associated with reduced p27 expression and increased apoptosis during late stage cyst progression upon inactivation of Pkd1 in collecting ducts.Cilia movement regulates expression of the Raf-1 kinase inhibitor protein The small GTPase Cdc42 is necessary for primary ciliogenesis in renal tubular epithelial cells.Altered trafficking and stability of polycystins underlie polycystic kidney disease.c-Src inactivation reduces renal epithelial cell-matrix adhesion, proliferation, and cyst formation Inactivation of integrin-β1 prevents the development of polycystic kidney disease after the loss of polycystin-1.Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling.Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease.Scattered Deletion of PKD1 in Kidneys Causes a Cystic Snowball Effect and Recapitulates Polycystic Kidney Disease Glycogen synthase kinase-3β promotes cyst expansion in polycystic kidney disease Polycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein Stability

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Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.

http://www.wikidata.org/entity/Q33985882

description

2008 nî lūn-bûn

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2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի փետրվարին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Cyst formation and activation ...... specific inactivation of Pkd1.

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Cyst formation and activation ...... specific inactivation of Pkd1.

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type

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Cyst formation and activation ...... specific inactivation of Pkd1.

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Cyst formation and activation ...... specific inactivation of Pkd1.

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Cyst formation and activation ...... specific inactivation of Pkd1.

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Cyst formation and activation ...... specific inactivation of Pkd1.

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Human Molecular Genetics

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Cyst formation and activation ...... specific inactivation of Pkd1

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Angeliki Louvi

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Heino Velazquez

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Lloyd G Cantley

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Michihiro Mitobe

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R Brent Thomson

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Saori Nishio

http://www.w3.org/2001/XMLSchema#string

Sekiya Shibazaki

http://www.w3.org/2001/XMLSchema#string

Shuta Ishibe

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Stefan Somlo

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Xin Tian

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P2860

Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells

Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene

Polycystin 1 is required for the structural integrity of blood vessels

Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis

Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor

High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

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1505-1516

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scholarly article

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10.1093/HMG/DDN039

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11

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17

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2008-02-07T00:00:00Z

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5587762

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18263604

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2902289

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