Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs.
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Zinc is essential for binding of p56(lck) to CD4 and CD8alphaInteraction of p56lck with CD4 in the yeast two-hybrid systemThe SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytesPhosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lckHuman immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tailp70 phosphorylation and binding to p56lck is an early event in interleukin-2-induced onset of cell cycle progression in T-lymphocytesAdhesion versus coreceptor function of CD4 and CD8: role of the cytoplasmic tail in coreceptor activityRACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cellsA Zn2+ ion links the cytoplasmic tail of CD4 and the N-terminal region of LckHuman immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activityMembrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human plateletsA novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptorThe integrity of the conserved 'WS motif' common to IL-2 and other cytokine receptors is essential for ligand binding and signal transductionTwo isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localizationMapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kThe T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitroAssociation of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transductionThe SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancerStructure determination of human Lck unique and SH3 domains by nuclear magnetic resonance spectroscopyT cell antigen recognition at the cell membraneKinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 bindingCharacterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequencesMHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selectionLck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid raftsLck availability during thymic selection determines the recognition specificity of the T cell repertoireIncorporation of 12-methoxydodecanoate into the human immunodeficiency virus 1 gag polyprotein precursor inhibits its proteolytic processing and virus production in a chronically infected human lymphoid cell lineCo-evolution from yeast to mouse: cDNA cloning of the two NF-Y (CP-1/CBF) subunitsAssociation of Src-like protein tyrosine kinases with the CD2 cell surface molecule in rat T lymphocytes and natural killer cellsRoles of C-terminal Src kinase in the initiation and the termination of the high affinity IgE receptor-mediated signalingInhibition of the plasma membrane Ca2+ pump by CD44 receptor activation of tyrosine kinases increases the action potential afterhyperpolarization in sensory neuronsT cell receptor bias for MHC: co-evolution or co-receptors?Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signalingBinding of src-like kinases to the beta-subunit of the interleukin-3 receptor.Role of the Lck Src homology 2 and 3 domains in protein tyrosine phosphorylation.Polyomavirus middle-T antigen associates with the kinase domain of Src-related tyrosine kinases.The unique amino-terminal domain of p56lck regulates interactions with tyrosine protein phosphatases in T lymphocytesActivated lck tyrosine protein kinase stimulates antigen-independent interleukin-2 production in T cells.
P2860
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P2860
Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs.
description
1990 nî lūn-bûn
@nan
1990 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի մարտին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Interaction of the unique N-te ...... s mediated by cysteine motifs.
@ast
Interaction of the unique N-te ...... s mediated by cysteine motifs.
@en
Interaction of the unique N-te ...... s mediated by cysteine motifs.
@nl
type
label
Interaction of the unique N-te ...... s mediated by cysteine motifs.
@ast
Interaction of the unique N-te ...... s mediated by cysteine motifs.
@en
Interaction of the unique N-te ...... s mediated by cysteine motifs.
@nl
prefLabel
Interaction of the unique N-te ...... s mediated by cysteine motifs.
@ast
Interaction of the unique N-te ...... s mediated by cysteine motifs.
@en
Interaction of the unique N-te ...... s mediated by cysteine motifs.
@nl
P2093
P1433
P1476
Interaction of the unique N-te ...... s mediated by cysteine motifs.
@en
P2093
Brodsky MH
Littman DR
Perlmutter RM
P304
P356
10.1016/0092-8674(90)90090-2
P407
P577
1990-03-01T00:00:00Z