Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways. - sprookjes - yvandenbroek - TriplyDB

Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways.

Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways.

http://www.wikidata.org/entity/Q34480890

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ZAP70: a master regulator of adaptive immunity Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site Comparison of T cell receptor-induced proximal signaling and downstream functions in immortalized and primary T cells Quantifying intramolecular binding in multivalent interactions: a structure-based synergistic study on Grb2-Sos1 complex Phosphorylation site dynamics of early T-cell receptor signaling GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production.The adaptor protein SAP directly associates with CD3ζ chain and regulates T cell receptor signaling.c-Cbl-mediated regulation of LAT-nucleated signaling complexes Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling Molecular mechanisms of T-cell receptor and costimulatory molecule ligation/blockade in autoimmune disease therapy.Therapeutic blockade of T-cell antigen receptor signal transduction and costimulation in autoimmune disease T-cell signaling regulated by the Tec family kinase, Itk.The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.Proline-rich tyrosine kinase 2 controls PI3-kinase activation downstream of the T cell antigen receptor in human T cells.TCR-mediated functions are enhanced in activated peripheral blood T cells isolated from leucocyte reduction systems.GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK Membrane dynamics correlate with formation of signaling clusters during cell spreading.Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation.Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism.Quantitative phosphoproteomic analysis reveals a role for serine and threonine kinases in the cytoskeletal reorganization in early T cell receptor activation in human primary T cells.A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.(-)-Epigallocatechin gallate regulates CD3-mediated T cell receptor signaling in leukemia through the inhibition of ZAP-70 kinase Glycerol Monolaurate (GML) inhibits human T cell signaling and function by disrupting lipid dynamics.Aggregation of membrane proteins by cytosolic cross-linkers: theory and simulation of the LAT-Grb2-SOS1 system Prior TLR5 induction in human T cells results in a transient potentiation of subsequent TCR-induced cytokine production.An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor.Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor.Distinct signaling pathways regulate TLR2 co-stimulatory function in human T cells.Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1.Activated PLC-γ1 is catalytically induced at LAT but activated PLC-γ1 is localized at both LAT- and TCR-containing complexes.ERK and cell death: ERK location and T cell selection.Lymphoproliferative disorders involving T helper effector cells with defective LAT signalosomes.The LAT story: a tale of cooperativity, coordination, and choreography.The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation.Integrative biology of T cell activation.Microtubule-associated protein-4 controls nanovesicle dynamics and T cell activation.Serine residues in the LAT adaptor are essential for TCR-dependent signal transduction.

P2860

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P2860

Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways.

http://www.wikidata.org/entity/Q34480890

description

2005 nî lūn-bûn

@nan

2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի օգոստոսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Early phosphorylation kinetics ...... R-mediated signaling pathways.

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Early phosphorylation kinetics ...... R-mediated signaling pathways.

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Early phosphorylation kinetics ...... R-mediated signaling pathways.

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type

label

Early phosphorylation kinetics ...... R-mediated signaling pathways.

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Early phosphorylation kinetics ...... R-mediated signaling pathways.

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Early phosphorylation kinetics ...... R-mediated signaling pathways.

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prefLabel

Early phosphorylation kinetics ...... R-mediated signaling pathways.

@ast

Early phosphorylation kinetics ...... R-mediated signaling pathways.

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Early phosphorylation kinetics ...... R-mediated signaling pathways.

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JIMMUNOL.175.4.2449

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Journal of Immunology

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Early phosphorylation kinetics ...... R-mediated signaling pathways.

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Jon C D Houtman

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Lawrence E Samelson

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Richard A Houghtling

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Yoko Toda

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P2860

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells

Positive and negative regulation of T-cell activation through kinases and phosphatases

Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT

GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation

The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

Essential role of LAT in T cell development

Staging and resetting T cell activation in SMACs

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4

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175

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Mira Barda-Saad

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2005-08-01T00:00:00Z

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7677911

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16081816

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phosphorylation

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1414060

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