Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.
about
Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression.Deletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementiaAPP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutantDanish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficitsIncreased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice.The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) OligomersMemory deficits of British dementia knock-in mice are prevented by Aβ-precursor protein haploinsufficiency.Proteomic characterization of a mouse model of familial Danish dementia.β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia.Lessons from a Rare Familial Dementia: Amyloid and Beyond.Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia.Increased AβPP processing in familial Danish dementia patients.Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memoryAmyloid peptides ABri and ADan show differential neurotoxicity in transgenic Drosophila models of familial British and Danish dementia.BRICHOS domain associated with lung fibrosis, dementia and cancer--a chaperone that prevents amyloid fibril formation?Abolishing Tau cleavage by caspases at Aspartate421 causes memory/synaptic plasticity deficits and pre-pathological Tau alterations.BRI2 protein regulates β-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE).The ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseases.BRI2 ectodomain affects Aβ42 fibrillation and tau truncation in human neuroblastoma cells.Transthyretin and BRICHOS: The Paradox of Amyloidogenic Proteins with Anti-Amyloidogenic Activity for Aβ in the Central Nervous System.Highly Expressed Genes within Hippocampal Sector CA1: Implications for the Physiology of Memory.Amyloid and intracellular accumulation of BRI2.A role for tau in learning, memory and synaptic plasticity.Identification and characterization of the BRI2 interactome in the brain.
P2860
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P2860
Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Memory deficits due to familia ...... ction rather than amyloidosis.
@ast
Memory deficits due to familia ...... ction rather than amyloidosis.
@en
Memory deficits due to familia ...... ction rather than amyloidosis.
@nl
type
label
Memory deficits due to familia ...... ction rather than amyloidosis.
@ast
Memory deficits due to familia ...... ction rather than amyloidosis.
@en
Memory deficits due to familia ...... ction rather than amyloidosis.
@nl
prefLabel
Memory deficits due to familia ...... ction rather than amyloidosis.
@ast
Memory deficits due to familia ...... ction rather than amyloidosis.
@en
Memory deficits due to familia ...... ction rather than amyloidosis.
@nl
P2093
P2860
P50
P1476
Memory deficits due to familia ...... ction rather than amyloidosis.
@en
P2093
Cristina d'Abramo
Luca Giliberto
Robert Tamayev
Ruben Vidal
P2860
P304
14915-14924
P356
10.1523/JNEUROSCI.3917-10.2010
P407
P577
2010-11-01T00:00:00Z