Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance.
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Antigenic peptide trimming by ER aminopeptidases--insights from structural studiesEndoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune responseStructural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen ProcessingRationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responsesNonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulumGenome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.ERAP1 reduces accumulation of aberrant and disulfide-linked forms of HLA-B27 on the cell surfaceCutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzymeBalancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation.The specificity of trimming of MHC class I-presented peptides in the endoplasmic reticulum.Characterizing the specificity and cooperation of aminopeptidases in the cytosol and endoplasmic reticulum during MHC class I antigen presentationPlacental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1A functional variant in ERAP1 predisposes to multiple sclerosis.Heterologous immunity: immunopathology, autoimmunity and protection during viral infections.Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus-specific CD8+ T-cell epitope.Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis.A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition.A panel of artificial APCs expressing prevalent HLA alleles permits generation of cytotoxic T cells specific for both dominant and subdominant viral epitopes for adoptive therapy.Endoplasmic reticulum aminopeptidase associated with antigen processing defines the composition and structure of MHC class I peptide repertoire in normal and virus-infected cells.Proteases in MHC class I presentation and cross-presentationAnalysis of the role of tripeptidyl peptidase II in MHC class I antigen presentation in vivoDifferences in genetic variation in antigen-processing machinery components and association with cervical carcinoma risk in two Indonesian populations.Pathogenesis of preeclampsia: the genetic componentEndoplasmic reticulum aminopeptidase 1 and rheumatic disease: functional variation.ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responsesPortable flanking sequences modulate CTL epitope processing.Role of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer.The genetics of human autoimmune disease: A perspective on progress in the field and future directions.ERAP1 genetic variations associated with HLA-B27 interaction and disease severity of syndesmophytes formation in Taiwanese ankylosing spondylitis.Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1Proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ Th cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigensComparative expression profiling for human endoplasmic reticulum-resident aminopeptidases 1 and 2 in normal kidney versus distinct renal cell carcinoma subtypesCoping with loss of perfection in the MHC class I peptide repertoire.Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum.HLA-B27 misfolding and spondyloarthropathies.Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity.The quality control of MHC class I peptide loading.Preventing tumor escape by targeting a post-proteasomal trimming independent epitope.
P2860
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P2860
Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance.
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Endoplasmic reticulum aminopep ...... rtant role in immunodominance.
@ast
Endoplasmic reticulum aminopep ...... rtant role in immunodominance.
@en
type
label
Endoplasmic reticulum aminopep ...... rtant role in immunodominance.
@ast
Endoplasmic reticulum aminopep ...... rtant role in immunodominance.
@en
prefLabel
Endoplasmic reticulum aminopep ...... rtant role in immunodominance.
@ast
Endoplasmic reticulum aminopep ...... rtant role in immunodominance.
@en
P2093
P2860
P356
P1476
Endoplasmic reticulum aminopep ...... ortant role in immunodominance
@en
P2093
Charles F Towne
Kenneth L Rock
Michael A Brehm
Sophia Zendzian
P2860
P304
P356
10.1073/PNAS.0603095103
P407
P50
P577
2006-06-05T00:00:00Z