Specific regional transcription of apolipoprotein E in human brain neurons - sprookjes - yvandenbroek - TriplyDB

Specific regional transcription of apolipoprotein E in human brain neurons

Specific regional transcription of apolipoprotein E in human brain neurons

http://www.wikidata.org/entity/Q35745315

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Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease Human APOE genotype affects intraneuronal Aβ1-42 accumulation in a lentiviral gene transfer model Proteolytic cleavage of apolipoprotein E4 as the keystone for the heightened risk associated with Alzheimer's disease Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease Non-steroidal anti-inflammatory drugs mediate increased in vitro glial expression of apolipoprotein E protein Expression of cholesterol homeostasis genes in the brain of the male rat is affected by age and dietary restriction GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice.Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors Stem cell derived basal forebrain cholinergic neurons from Alzheimer's disease patients are more susceptible to cell death.Apolipoprotein-E forms dimers in human frontal cortex and hippocampus Apolipoprotein E mRNA is transported to dendrites and may have a role in synaptic structural plasticity.APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure.Nuclear uptake of an amino-terminal fragment of apolipoprotein E4 promotes cell death and localizes within microglia of the Alzheimer's disease brain.Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease.Apolipoprotein E gene promoter polymorphisms in Alzheimer's disease.APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease.Apolipoprotein E and Alzheimer disease: an update on genetic and functional analyses.Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity Apolipoprotein E: from lipid transport to neurobiology Genetics of Alzheimer disease Function and comorbidities of apolipoprotein e in Alzheimer's disease.Neuroplasticity in Alzheimer's disease.Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice Activation of estrogen receptor alpha increases and estrogen receptor beta decreases apolipoprotein E expression in hippocampus in vitro and in vivo.Cholesterol metabolism and homeostasis in the brain The allelic modulation of apolipoprotein E expression by oestrogen: potential relevance for Alzheimer's disease.Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice.Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord.Impairments in spatial memory retention of GFAP-apoE4 female mice.Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice Cholesterol: its regulation and role in central nervous system disorders.Pallidal neuronal apolipoprotein E in pantothenate kinase-associated neurodegeneration recapitulates ischemic injury to the globus pallidus.Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology.Links between copper and cholesterol in Alzheimer's disease.Apolipoprotein E and cholesterol in aging and disease in the brain Apolipoprotein E and Alzheimer's disease: molecular mechanisms and therapeutic opportunities.Following activation of the amyloid cascade, apolipoprotein E4 drives the in vivo oligomerization of amyloid-β resulting in neurodegeneration.Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease.

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P2860

Specific regional transcription of apolipoprotein E in human brain neurons

http://www.wikidata.org/entity/Q35745315

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Specific regional transcription of apolipoprotein E in human brain neurons

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Specific regional transcription of apolipoprotein E in human brain neurons

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Specific regional transcription of apolipoprotein E in human brain neurons

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Specific regional transcription of apolipoprotein E in human brain neurons

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Specific regional transcription of apolipoprotein E in human brain neurons

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The American Journal of Pathology

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Specific regional transcription of apolipoprotein E in human brain neurons

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P2860

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

Neuropathological stageing of Alzheimer-related changes

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

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