Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining.
about
Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repairCDK targets Sae2 to control DNA-end resection and homologous recombinationReplication protein A prevents promiscuous annealing between short sequence homologies: Implications for genome integrityThe Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changesCompeting roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination.Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex.Yeast Nej1 is a key participant in the initial end binding and final ligation steps of nonhomologous end joining.Cyclin-dependent kinase-dependent phosphorylation of Lif1 and Sae2 controls imprecise nonhomologous end joining accompanied by double-strand break resection.Microarray-based genetic screen defines SAW1, a gene required for Rad1/Rad10-dependent processing of recombination intermediatesDNA polymerase θ (POLQ), double-strand break repair, and cancerBalancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too?Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?Current technologies and related issues for mushroom transformationERCC1-XPF endonuclease facilitates DNA double-strand break repairDNA ligases I and III cooperate in alternative non-homologous end-joining in vertebratesMechanism of suppression of chromosomal instability by DNA polymerase POLQSae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling.MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endingsDNA repair pathway selection caused by defects in TEL1, SAE2, and de novo telomere addition generates specific chromosomal rearrangement signatures.Small deletion variants have stable breakpoints commonly associated with alu elements.A microhomology-mediated break-induced replication model for the origin of human copy number variation.The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevisMicrohomology-mediated end joining induces hypermutagenesis at breakpoint junctions.Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila.Genomic characterization of large rearrangements of the LDLR gene in Czech patients with familial hypercholesterolemiaMechanisms of chromosome number evolution in yeast.Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes.Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions.Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cellsATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joiningRPA coordinates DNA end resection and prevents formation of DNA hairpins.Yeast pol4 promotes tel1-regulated chromosomal translocations.RPA antagonizes microhomology-mediated repair of DNA double-strand breaks.Identification of novel radiosensitizers in a high-throughput, cell-based screen for DSB repair inhibitors.Sumoylation influences DNA break repair partly by increasing the solubility of a conserved end resection protein.Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.DNA damage response factors from diverse pathways, including DNA crosslink repair, mediate alternative end joining.An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathwayThe MRX Complex Ensures NHEJ Fidelity through Multiple Pathways Including Xrs2-FHA-Dependent Tel1 Activation.
P2860
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P2860
Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Saccharomyces cerevisiae Sae2- ...... homology-mediated end joining.
@ast
Saccharomyces cerevisiae Sae2- ...... homology-mediated end joining.
@en
type
label
Saccharomyces cerevisiae Sae2- ...... homology-mediated end joining.
@ast
Saccharomyces cerevisiae Sae2- ...... homology-mediated end joining.
@en
prefLabel
Saccharomyces cerevisiae Sae2- ...... homology-mediated end joining.
@ast
Saccharomyces cerevisiae Sae2- ...... homology-mediated end joining.
@en
P2860
P1433
P1476
Saccharomyces cerevisiae Sae2- ...... homology-mediated end joining.
@en
P2093
Kihoon Lee
Sang Eun Lee
P2860
P304
P356
10.1534/GENETICS.107.076539
P407
P577
2007-06-11T00:00:00Z