Pleiotrophin transforms NIH 3T3 cells and induces tumors in nude mice.
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Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zetaSolution structure of midkine, a new heparin-binding growth factorDomain structure of pleiotrophin required for transformationIdentification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophinMidkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell typesPleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growthA Receptor-like Protein-tyrosine Phosphatase PTP /RPTP Binds a Heparin-binding Growth Factor Midkine: INVOLVEMENT OF ARGININE 78 OF MIDKINE IN THE HIGH AFFINITY BINDING TO PTPInvolvement of heparin affin regulatory peptide in human prostate cancer.Pleiotrophin induces angiogenesis: involvement of the phosphoinositide-3 kinase but not the nitric oxide synthase pathways.Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/ConneStructure and phylogenetic analysis of an endogenous retrovirus inserted into the human growth factor gene pleiotrophin.The synthetic peptide P111-136 derived from the C-terminal domain of heparin affin regulatory peptide inhibits tumour growth of prostate cancer PC-3 cells.Pleiotrophin regulates serine phosphorylation and the cellular distribution of beta-adducin through activation of protein kinase CThe role of pleiotrophin and beta-catenin in fetal lung development.A Pleiotrophin C-terminus peptide induces anti-cancer effects through RPTPβ/ζChicken pleiotrophin: regulation of tissue specific expression by estrogen in the oviduct and distinct expression pattern in the ovarian carcinomasTranslocations involving anaplastic lymphoma kinase (ALK).Pleiotrophin (PTN) expression and function and in the mouse mammary gland and mammary epithelial cells.PTN signaling: Components and mechanistic insights in human ovarian cancer.Receptor protein tyrosine phosphatase zeta as a therapeutic target for glioblastoma therapy.Secretion of pleiotrophin stimulates breast cancer progression through remodeling of the tumor microenvironment.Truncated midkine as a marker of diagnosis and detection of nodal metastases in gastrointestinal carcinomas.Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway.A dominant-negative pleiotrophin mutant introduced by homologous recombination leads to germ-cell apoptosis in male mice.Loss of receptor protein tyrosine phosphatase β/ζ (RPTPβ/ζ) promotes prostate cancer metastasisMelanoma angiogenesis and metastasis modulated by ribozyme targeting of the secreted growth factor pleiotrophinHuman trophoblast and choriocarcinoma expression of the growth factor pleiotrophin attributable to germ-line insertion of an endogenous retrovirus.Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy.Protein tyrosine phosphatases in glioma biologyPTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin.Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.Pleiotrophin exerts its migration and invasion effect through the neuropilin-1 pathwayRegulation of sarcoma cell migration, invasion and invadopodia formation by AFAP1L1 through a phosphotyrosine-dependent pathway.GM3 suppresses anchorage-independent growth via Rho GDP dissociation inhibitor beta in melanoma B16 cells.Midkine induces the transformation of NIH3T3 cells.RNA interference targeting protein tyrosine phosphatase zeta/receptor-type protein tyrosine phosphatase beta suppresses glioblastoma growth in vitro and in vivo.Functional comparison of long and short splice forms of RPTPbeta: implications for glioblastoma treatment.Expression and function of the receptor protein tyrosine phosphatase zeta and its ligand pleiotrophin in human astrocytomas.Transformation by ras suppresses expression of the neurotrophic growth factor pleiotrophin.Human breast cancer growth inhibited in vivo by a dominant negative pleiotrophin mutant.
P2860
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P2860
Pleiotrophin transforms NIH 3T3 cells and induces tumors in nude mice.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Pleiotrophin transforms NIH 3T3 cells and induces tumors in nude mice.
@ast
Pleiotrophin transforms NIH 3T3 cells and induces tumors in nude mice.
@en
type
label
Pleiotrophin transforms NIH 3T3 cells and induces tumors in nude mice.
@ast
Pleiotrophin transforms NIH 3T3 cells and induces tumors in nude mice.
@en
prefLabel
Pleiotrophin transforms NIH 3T3 cells and induces tumors in nude mice.
@ast
Pleiotrophin transforms NIH 3T3 cells and induces tumors in nude mice.
@en
P2093
P2860
P356
P1476
Pleiotrophin transforms NIH 3T3 cells and induces tumors in nude mice.
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.2.679
P407
P577
1993-01-01T00:00:00Z