Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation
about
Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signallingMED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signalingAf9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortexThe epigenetic landscape of addictionMediator and cohesin connect gene expression and chromatin architectureMED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expressionImportance of Mediator complex in the regulation and integration of diverse signaling pathways in plantsMediator kinase module and human tumorigenesisThe Mediator complex: a central integrator of transcriptionDo all roads lead to Rome? The role of neuro-immune interactions before birth in the programming of offspring obesityMediator-dependent nuclear receptor functionDrosophila melanogaster Hox transcription factors access the RNA polymerase II machinery through direct homeodomain binding to a conserved motif of mediator subunit Med19The human Mediator complex: a versatile, genome-wide regulator of transcriptionThe Mediator complex and transcription regulationThe transcriptional mediator component Med12 is required for hindbrain boundary formationMouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis.G9a influences neuronal subtype specification in striatumStem cells have different needs for RESTControl of the embryonic stem cell stateIKKbeta mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cellsControl of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex.The MED12-MED13 module of Mediator regulates the timing of embryo patterning in ArabidopsisThe transcription factor REST is lost in aggressive breast cancer.Human negative elongation factor activates transcription and regulates alternative transcription initiation.Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.Epigenetic regulation of learning and memory by Drosophila EHMT/G9a.Mediator and human diseaseA muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolismA phosphotyrosine switch determines the antitumor activity of ERβ.Mediator subunit 12 is required for neutrophil development in zebrafishYin and yang of mediator function revealed by human mutantsTranscriptional regulation and its misregulation in disease.CDK19 is disrupted in a female patient with bilateral congenital retinal folds, microcephaly and mild mental retardation.CDK8 is a positive regulator of transcriptional elongation within the serum response network.Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott-Aldrich syndrome.Mediator acts upstream of the transcriptional activator Gal4.The functions of Mediator in Candida albicans support a role in shaping species-specific gene expression.Disruption of an EHMT1-associated chromatin-modification module causes intellectual disabilityLiver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity.REST and CoREST are transcriptional and epigenetic regulators of seminal neural fate decisions.
P2860
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P2860
Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Mediator links epigenetic sile ...... th x-linked mental retardation
@en
type
label
Mediator links epigenetic sile ...... th x-linked mental retardation
@en
prefLabel
Mediator links epigenetic sile ...... th x-linked mental retardation
@en
P2093
P2860
P1433
P1476
Mediator links epigenetic sile ...... th x-linked mental retardation
@en
P2093
Charles E Schwartz
Haiying Zhou
Hang Gyeong Chin
Michael J Friez
Pierre-Olivier Esteve
Seokjoong Kim
Sriharsa Pradhan
Sumy M Joseph
Thomas G Boyer
P2860
P304
P356
10.1016/J.MOLCEL.2008.05.023
P577
2008-08-01T00:00:00Z