CLC-0 and CFTR: chloride channels evolved from transporters.
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Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycleMolecular mechanism of proton transport in CLC Cl-/H+ exchange transportersCalcium-dependent phospholipid scramblase activity of TMEM16 protein family members13C NMR detects conformational change in the 100-kD membrane transporter ClC-ec1.The Concise Guide to PHARMACOLOGY 2013/14: ion channels"Off-on" aggregation-based fluorescent sensor for the detection of chloride in waterAccessibility of the CLC-0 pore to charged methanethiosulfonate reagents.CFTR and TNR-CFTR expression and function in the kidney.Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations.Antiport mechanism for Cl(-)/H(+) in ClC-ec1 from normal-mode analysis.Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channelDual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation.Optimization of the degenerated interfacial ATP binding site improves the function of disease-related mutant cystic fibrosis transmembrane conductance regulator (CFTR) channels.On the mechanism of CFTR inhibition by a thiazolidinone derivative.Modulation of CFTR gating by permeant ions.Localizing a gate in CFTR.Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels.Full-open and closed CFTR channels, with lateral tunnels from the cytoplasm and an alternative position of the F508 region, as revealed by molecular dynamics.Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7).Molecular dynamics investigation of Cl- and water transport through a eukaryotic CLC transporter.Cystic fibrosis transmembrane conductance regulator: a molecular model defines the architecture of the anion conduction path and locates a "bottleneck" in the pore.Differential regulation of a CLC anion channel by SPAK kinase ortholog-mediated multisite phosphorylation.The CFTR ion channel: gating, regulation, and anion permeationCysteine scanning of CFTR's first transmembrane segment reveals its plausible roles in gating and permeationMultiscale Simulations Reveal Key Aspects of the Proton Transport Mechanism in the ClC-ec1 Antiporter.Spatial positioning of CFTR's pore-lining residues affirms an asymmetrical contribution of transmembrane segments to the anion permeation pathwayThree-dimensional reconstruction of human cystic fibrosis transmembrane conductance regulator chloride channel revealed an ellipsoidal structure with orifices beneath the putative transmembrane domainMutations at the signature sequence of CFTR create a Cd(2+)-gated chloride channel.Identification of regulatory phosphorylation sites in a cell volume- and Ste20 kinase-dependent ClC anion channel.Nonequilibrium gating of CFTR on an equilibrium theme.A stable ATP binding to the nucleotide binding domain is important for reliable gating cycle in an ABC transporter CFTR.State-dependent modulation of CFTR gating by pyrophosphate.Novel diuretic targetsApplication of rate-equilibrium free energy relationship analysis to nonequilibrium ion channel gating mechanismsReview. ATP hydrolysis-driven gating in cystic fibrosis transmembrane conductance regulator.Molecular modeling of the heterodimer of human CFTR's nucleotide-binding domains using a protein-protein docking approachGating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation.Water access points and hydration pathways in CLC H+/Cl- transporters.Genetically encoded optical sensors for monitoring of intracellular chloride and chloride-selective channel activity.Catalyst-like modulation of transition states for CFTR channel opening and closing: new stimulation strategy exploits nonequilibrium gating.
P2860
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P2860
CLC-0 and CFTR: chloride channels evolved from transporters.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on April 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
CLC-0 and CFTR: chloride channels evolved from transporters.
@en
CLC-0 and CFTR: chloride channels evolved from transporters.
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type
label
CLC-0 and CFTR: chloride channels evolved from transporters.
@en
CLC-0 and CFTR: chloride channels evolved from transporters.
@nl
prefLabel
CLC-0 and CFTR: chloride channels evolved from transporters.
@en
CLC-0 and CFTR: chloride channels evolved from transporters.
@nl
P2860
P1476
CLC-0 and CFTR: chloride channels evolved from transporters.
@en
P2093
Tsung-Yu Chen
Tzyh-Chang Hwang
P2860
P304
P356
10.1152/PHYSREV.00058.2006
P577
2008-04-01T00:00:00Z