Mammalian target of rapamycin repression by 3,3'-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-D-overexpressing PC3 cells
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Updates of mTOR inhibitorsEmerging roles of PDGF-D in EMT progression during tumorigenesisThe complexities of epidemiology and prevention of gastrointestinal cancersDisruptive chemicals, senescence and immortalityActivation of AMP-activated protein kinase by 3,3'-Diindolylmethane (DIM) is associated with human prostate cancer cell death in vitro and in vivoHypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatmentLeucine signaling in the pathogenesis of type 2 diabetes and obesityEpithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cellsChemopreventive agent 3,3'-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases.Androgen receptor as a driver of therapeutic resistance in advanced prostate cancer.Emerging roles of PDGF-D signaling pathway in tumor development and progression.3,3'-diindolylmethane enhances the efficacy of butyrate in colon cancer prevention through down-regulation of survivinAttenuation of multi-targeted proliferation-linked signaling by 3,3'-diindolylmethane (DIM): from bench to clinic.The complexes of mammalian target of rapamycin.Novel targets for prostate cancer chemoprevention.Safety and tolerability of DIM-based therapy designed as personalized approach to reverse prostatic intraepithelial neoplasia (PIN).Multiple therapeutic and preventive effects of 3,3'-diindolylmethane on cancers including prostate cancer and high grade prostatic intraepithelial neoplasia.Hypoxia induced aggressiveness of prostate cancer cells is linked with deregulated expression of VEGF, IL-6 and miRNAs that are attenuated by CDF.Histone deacetylase inhibitors induce epithelial-to-mesenchymal transition in prostate cancer cells.Androgen receptor splice variants contribute to prostate cancer aggressiveness through induction of EMT and expression of stem cell marker genes.Ring-substituted analogs of 3,3'-diindolylmethane (DIM) induce apoptosis and necrosis in androgen-dependent and -independent prostate cancer cells.miR-200 regulates PDGF-D-mediated epithelial-mesenchymal transition, adhesion, and invasion of prostate cancer cells.PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer.Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma in A/J mice when administered during the post-initiation or progression phase of lung tumorigenesis.Epigenetic silencing of miR-34a in human prostate cancer cells and tumor tissue specimens can be reversed by BR-DIM treatment3,3'-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and -independent prostate cancer cells.3,3'-Diindolylmethane: A Promising Sensitizer of γ-IrradiationThe impact of cow's milk-mediated mTORC1-signaling in the initiation and progression of prostate cancerChemoprevention of lung tumorigenesis by intranasally administered diindolylmethane in A/J mice.Role of BioResponse 3,3'-Diindolylmethane in the Treatment of Human Prostate Cancer: Clinical Experience.Mechanisms and therapeutic implications of cell death induction by indole compounds.Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cellsActivated K-Ras and INK4a/Arf deficiency promote aggressiveness of pancreatic cancer by induction of EMT consistent with cancer stem cell phenotype.Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention.DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism.Chemopreventive properties of 3,3'-diindolylmethane in breast cancer: evidence from experimental and human studies.RETRACTED: 3,3'-Diindolylmethane enhances chemosensitivity of multiple chemotherapeutic agents in pancreatic cancer.Nicotinic acetylcholine receptor antagonists alter the function and expression of serine racemase in PC-12 and 1321N1 cells.Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells.Systems and Network Pharmacology Approaches to Cancer Stem Cells Research and Therapy.
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P2860
Mammalian target of rapamycin repression by 3,3'-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-D-overexpressing PC3 cells
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Mammalian target of rapamycin ...... tor-D-overexpressing PC3 cells
@en
Mammalian target of rapamycin ...... or-D-overexpressing PC3 cells.
@nl
type
label
Mammalian target of rapamycin ...... tor-D-overexpressing PC3 cells
@en
Mammalian target of rapamycin ...... or-D-overexpressing PC3 cells.
@nl
prefLabel
Mammalian target of rapamycin ...... tor-D-overexpressing PC3 cells
@en
Mammalian target of rapamycin ...... or-D-overexpressing PC3 cells.
@nl
P2093
P2860
P1433
P1476
Mammalian target of rapamycin ...... tor-D-overexpressing PC3 cells
@en
P2093
Dejuan Kong
Fazlul H Sarkar
Hyeong-Reh Choi Kim
Sanjeev Banerjee
Zhiwei Wang
P2860
P304
P356
10.1158/0008-5472.CAN-07-3241
P407
P577
2008-03-01T00:00:00Z