Monoclonal antibodies to an interferon-induced Mr 68,000 protein and their use for the detection of double-stranded RNA-dependent protein kinase in human cells.
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The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKRLatently expressed human herpesvirus 8-encoded interferon regulatory factor 2 inhibits double-stranded RNA-activated protein kinase.Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPKThe mRNA of the translationally controlled tumor protein P23/TCTP is a highly structured RNA, which activates the dsRNA-dependent protein kinase PKRAlpha interferon induces distinct translational control programs to suppress hepatitis C virus RNA replicationTranslational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinaseAutophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKRImpact of protein kinase PKR in cell biology: from antiviral to antiproliferative actionSmall interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral productionSystem-based proteomic analysis of the interferon response in human liver cellsControl of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesisAntiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinaseCharacterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKRHepatitis C virus controls interferon production through PKR activationAn antiviral response directed by PKR phosphorylation of the RNA helicase AIn vitro activation of the interferon-induced, double-stranded RNA-dependent protein kinase PKR by RNA from the 3' untranslated regions of human alpha-tropomyosin.Purification and partial characterization of a cellular inhibitor of the interferon-induced protein kinase of Mr 68,000 from influenza virus-infected cells.Thioredoxin reductase mediates cell death effects of the combination of beta interferon and retinoic acid.Hepatitis C virus envelope protein E2 does not inhibit PKR by simple competition with autophosphorylation sites in the RNA-binding domain.Adenovirus VAI RNA complexes with the 68 000 Mr protein kinase to regulate its autophosphorylation and activityHepatitis C virus reveals a novel early control in acute immune response.Structural features of adenovirus 2 virus-associated RNA required for binding to the protein kinase DAI.Paradoxical interactions between human delta hepatitis agent RNA and the cellular protein kinase PKRNeutralizing antibodies against the V3 loop of human immunodeficiency virus type 1 gp120 block the CD4-dependent and -independent binding of virus to cells.Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase.The testicular antiviral defense system: localization, expression, and regulation of 2'5' oligoadenylate synthetase, double-stranded RNA-activated protein kinase, and Mx proteins in the rat seminiferous tubule.Disruption of cellular translational control by a viral truncated eukaryotic translation initiation factor 2alpha kinase homolog.Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation.Interaction of the interferon-induced PKR protein kinase with inhibitory proteins P58IPK and vaccinia virus K3L is mediated by unique domains: implications for kinase regulationStructural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2 alpha kinase DAI in Saccharomyces cerevisiae.Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha.Degradation of the interferon-induced 68,000-M(r) protein kinase by poliovirus requires RNAThe integrity of the stem structure of human immunodeficiency virus type 1 Tat-responsive sequence of RNA is required for interaction with the interferon-induced 68,000-Mr protein kinaseFunctional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free systemPurification and activation of the double-stranded RNA-dependent eIF-2 kinase DAIThe cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation.Production of a monoclonal antibody directed against an interferon-induced 56,000-dalton protein and its use in the study of this protein.Influenza virus regulates protein synthesis during infection by repressing autophosphorylation and activity of the cellular 68,000-Mr protein kinase.Activation of double-stranded RNA-activated protein kinase in HeLa cells after poliovirus infection does not result in increased phosphorylation of eucaryotic initiation factor-2
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P2860
Monoclonal antibodies to an interferon-induced Mr 68,000 protein and their use for the detection of double-stranded RNA-dependent protein kinase in human cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 1985
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Monoclonal antibodies to an in ...... protein kinase in human cells.
@en
Monoclonal antibodies to an in ...... protein kinase in human cells.
@nl
type
label
Monoclonal antibodies to an in ...... protein kinase in human cells.
@en
Monoclonal antibodies to an in ...... protein kinase in human cells.
@nl
prefLabel
Monoclonal antibodies to an in ...... protein kinase in human cells.
@en
Monoclonal antibodies to an in ...... protein kinase in human cells.
@nl
P2093
P2860
P356
P1476
Monoclonal antibodies to an in ...... protein kinase in human cells.
@en
P2093
P2860
P304
P356
10.1073/PNAS.82.13.4341
P407
P577
1985-07-01T00:00:00Z