Arsenical-resistant trypanosomes lack an unusual adenosine transporter.
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Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2·Keap1·Cul3 complex and recruiting Nrf2·Maf to the antioxidant response element enhancerCritical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2Trypanothione overproduction and resistance to antimonials and arsenicals in LeishmaniaIn vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasisCrystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and HyperactivationIsolation and functional characterization of the PfNT1 nucleoside transporter gene from Plasmodium falciparumNew Approaches to Overcome Transport Related Drug Resistance in Trypanosomatid ParasitesTrypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stressA chlorodiazirine analog of pentamidine with anti-trypanosomal activityPreclinical assessment of the treatment of second-stage African trypanosomiasis with cordycepin and deoxycoformycinGenotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawalA molecular mechanism for eflornithine resistance in African trypanosomesIsolation of Trypanosoma brucei gambiense from cured and relapsed sleeping sickness patients and adaptation to laboratory miceUntargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma bruceiAquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprolQuinone-amino acid conjugates targeting Leishmania amino acid transportersSpecific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African TrypanosomiasisTransport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma bruceiDrug resistance in eukaryotic microorganisms.Protein crystallography and infectious diseases.The adenosine transporter of Toxoplasma gondii. Identification by insertional mutagenesis, cloning, and recombinant expression.Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasisPredictive computational models of substrate binding by a nucleoside transporter.Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes.The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control.Symmetrical choline-derived dications display strong anti-kinetoplastid activity.Combination chemotherapy of drug-resistant Trypanosoma brucei rhodesiense infections in mice using DL-alpha-difluoromethylornithine and standard trypanocides.Drug uptake via nutrient transporters in Trypanosoma brucei.Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif.Interaction of monobenzamidine-linked trypanocides with the Trypanosoma brucei P2 aminopurine transporterResistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion.The ENT family of eukaryote nucleoside and nucleobase transporters: recent advances in the investigation of structure/function relationships and the identification of novel isoforms.Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human african trypanosomiasis.Pathways of arsenic uptake and efflux.Biochemical and molecular mechanisms of drug resistance in parasites.Genetic dissection of drug resistance in trypanosomesRegulation of a high-affinity diamine transport system in Trypanosoma cruzi epimastigotes.Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns.The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomesNutrient transport and pathogenesis in selected parasitic protozoa.
P2860
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P2860
Arsenical-resistant trypanosomes lack an unusual adenosine transporter.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Arsenical-resistant trypanosomes lack an unusual adenosine transporter.
@en
type
label
Arsenical-resistant trypanosomes lack an unusual adenosine transporter.
@en
prefLabel
Arsenical-resistant trypanosomes lack an unusual adenosine transporter.
@en
P356
P1433
P1476
Arsenical-resistant trypanosomes lack an unusual adenosine transporter.
@en
P2093
P2888
P304
P356
10.1038/361173A0
P407
P577
1993-01-01T00:00:00Z
P5875
P6179
1022937714