Structure-Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469.
about
Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptorPharmacology and physiology of gastrointestinal enteroendocrine cellsIndomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice.Discovery of DS-1558: A Potent and Orally Bioavailable GPR40 AgonistMaking Dimethylamino a Transformable Directing Group by Nickel-Catalyzed C-N Borylation.Reevaluation of fatty acid receptor 1 as a drug target for the stimulation of insulin secretion in humans.Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4.Treatment of type 2 diabetes by free Fatty Acid receptor agonists.In vitro and mouse in vivo characterization of the potent free fatty acid 1 receptor agonist TUG-469.Free Fatty Acid Receptor 1 (FFAR1) as an Emerging Therapeutic Target for Type 2 Diabetes Mellitus: Recent Progress and Prevailing Challenges.Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist.Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles.Improving the Pharmacokinetics of GPR40/FFA1 Full AgonistsDiscovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes.Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets.SAR Studies of Indole-5-propanoic Acid Derivatives To Develop Novel GPR40 Agonists.Structural basis for the agonist action at free fatty acid receptor 1 (FFA1R or GPR40).Design and Synthesis of Novel, Selective GPR40 AgoPAMs.Ligands at Free Fatty Acid Receptor 1 (GPR40).Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms.
P2860
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P2860
Structure-Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Structure-Activity Study of Di ...... FFA1 (GPR40) Agonist TUG-469.
@en
Structure-Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1
@nl
type
label
Structure-Activity Study of Di ...... FFA1 (GPR40) Agonist TUG-469.
@en
Structure-Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1
@nl
prefLabel
Structure-Activity Study of Di ...... FFA1 (GPR40) Agonist TUG-469.
@en
Structure-Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1
@nl
P2093
P2860
P356
P1476
Structure-Activity Study of Di ...... t FFA1 (GPR40) Agonist TUG-469
@en
P2093
Alexandra Hamacher
Christel Drewke
Christian Urban
Evi Kostenis
Johannes Schmidt
Karsten Kristiansen
Kasper K Karlsen
Maria E Due-Hansen
Matthias U Kassack
Mette Steensgaard
P2860
P304
P356
10.1021/ML100106C
P577
2010-07-02T00:00:00Z